Diffusion-weighted magnetic resonance spectroscopy enables cell-specific monitoring of astrocyte reactivity $in\ vivo$
In: NeuroImage NeuroImage, Elsevier, 2019, 191, pp.457-469. ⟨10.1016/j.neuroimage.2019.02.046⟩ NeuroImage, 2019, 191, pp.457-469. ⟨10.1016/j.neuroimage.2019.02.046⟩; (2019-05-01)
Online
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Zugriff:
International audience; Reactive astrocytes exhibit hypertrophic morphology and altered metabolism. Deciphering astrocytic status would be of great importance to understand their role and dysregulation in pathologies, but most analytical methods remain highly invasive or destructive. The diffusion of brain metabolites, as non-invasively measured using diffusion-weighted magnetic resonance spectroscopy (DW-MRS) $in\ vivo$, depends on the structure of their micro-environment. Here we perform advanced DW-MRS in a mouse model of reactive astrocytes to determine how cellular compartments confining metabolite diffusion are changing. This reveals myo-inositol as a specific intra-astrocytic marker whose diffusion closely reflects astrocytic morphology, enabling non-invasive detection of astrocyte hypertrophy (subsequently confirmed by confocal microscopy $ex\ vivo$). Furthermore, we measure massive variations of lactate diffusion properties, suggesting that intracellular lactate is predominantly astrocytic under control conditions, but predominantly neuronal in case of astrocyte reactivity. This indicates massive remodeling of lactate metabolism, as lactate compartmentation is tightly linked to the astrocyte-to-neuron lactate shuttle mechanism.
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Diffusion-weighted magnetic resonance spectroscopy enables cell-specific monitoring of astrocyte reactivity $in\ vivo$
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Autor/in / Beteiligte Person: | Bonvento, Gilles ; Hernández-Garzón, Edwin ; Valette, Julien ; Escartin, Carole ; Flament, Julien ; Maria-Angeles Carrillo-de Sauvage ; Ligneul, Clémence ; Palombo, Marco ; Brouillet, Emmanuel ; Hantraye, Philippe ; Laboratoire des Maladies Neurodégénératives - UMR 9199 (LMN) ; Centre National de la Recherche Scientifique (CNRS)-Service MIRCEN (MIRCEN) ; Université Paris-Saclay-Institut de Biologie François JACOB (JACOB) ; Direction de Recherche Fondamentale (CEA) (DRF (CEA)) ; Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)) ; Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Institut de Biologie François JACOB (JACOB) ; Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA) ; Computer science department [University College London] (UCL-CS) ; University College of London [London] (UCL) ; Institut National de la Santé et de la Recherche Médicale (INSERM) ; European Project: 336331,EC:FP7:ERC,ERC-2013-StG,INCELL(2013) ; Service MIRCEN (MIRCEN) ; Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie François JACOB (JACOB) ; Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie François JACOB (JACOB) ; Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS) ; Department of Computer science [University College of London] (UCL-CS) |
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Quelle: | NeuroImage NeuroImage, Elsevier, 2019, 191, pp.457-469. ⟨10.1016/j.neuroimage.2019.02.046⟩ NeuroImage, 2019, 191, pp.457-469. ⟨10.1016/j.neuroimage.2019.02.046⟩; (2019-05-01) |
Veröffentlichung: | HAL CCSD, 2019 |
Medientyp: | unknown |
ISSN: | 1053-8119 (print) ; 1095-9572 (print) |
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