A high-resolution genetic map of the nervous locus on mouse chromosome 8
In: Genomics, Jg. 48 (1998-04-18), Heft 3
Online
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Zugriff:
The nervous (nr) mutant mouse displays two gross recessive traits: both an exaggeration of juvenile hyperactivity and a pronounced ataxia become apparent during the third and fourth postnatal weeks. Using an intersubspecific intercross, we have established a high-resolution map of a segment of mouse chromosome 8 that places the nr locus in a genomic segment defined by D8Rck1 on the centromeric end and D8Mit3 on the telomeric end. This map position places the nr locus within the BALB/cGr congenic region of the C3HeB/ FeJ-nr strain, confirming the accuracy of our study. We used this map position to identify and evaluate three genes-ankyrin 1, cortexin, and farnesyltransferase-as candidates for the nr gene. These three genes were eliminated from consideration but allowed us to establish the conservation of synteny between the region containing the nr locus and a segment of the short arm of human chromosome 8 (8p21-p11.2). Finally, the incomplete penetrance of the nr phenotype led us to perform a screen for modifier loci, and we present evidence that such a nervous modifier locus may exist on mouse chromosome 5.
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A high-resolution genetic map of the nervous locus on mouse chromosome 8
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Autor/in / Beteiligte Person: | Philip L. De Jager ; Zuo, Jian ; Polydorides, Alexandros D. ; Heintz, Nathaniel ; Harvey, Diane |
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Zeitschrift: | Genomics, Jg. 48 (1998-04-18), Heft 3 |
Veröffentlichung: | 1998 |
Medientyp: | unknown |
ISSN: | 0888-7543 (print) |
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