Hyperammonemia in a case of herpes simplex and anti-N-methyl-d-aspartate receptor encephalitis
In: Brain and Development, Jg. 41 (2019-08-01), S. 634-637
Online
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Zugriff:
Herpes simplex encephalitis (HSE) is a widely accepted risk factor for anti N-methyl-d-aspartate receptor (NMDAR) encephalitis. Association of inherited metabolic disease has never been reported in a patient with HSE and anti-NMDAR encephalitis. Herein, we report a case of pediatric HSE complicated by development of anti-NMDAR encephalitis; this patient showed subsequent recurrent, unexplained episodes of encephalopathy associated with hyperammonemia. The patient was diagnosed with lysinuric protein intolerance (LPI), a rare inborn metabolic disorder. Although it would be difficult to make conclusions regarding the casual link of HSE and anti-NMDAR encephalitis with LPI from a single case, there have been many reports that autoimmune diseases and immunologic abnormalities are frequently associated with LPI. Thus, we speculate that LPI may contribute to the development of anti-NMDAR encephalitis following HSE.
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Hyperammonemia in a case of herpes simplex and anti-N-methyl-d-aspartate receptor encephalitis
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Autor/in / Beteiligte Person: | Ki Joong Kim ; Soo Yeon Kim ; Jung Min Ko ; Jun Hwa Lee ; Woo Joong Kim ; Jong Hee Chae ; Byung Chan Lim |
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Zeitschrift: | Brain and Development, Jg. 41 (2019-08-01), S. 634-637 |
Veröffentlichung: | Elsevier BV, 2019 |
Medientyp: | unknown |
ISSN: | 0387-7604 (print) |
DOI: | 10.1016/j.braindev.2019.03.013 |
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