Prospective, large-scale multicenter trial for the use of drug-coated balloons in coronary lesions: The DCB-only All-Comers Registry
In: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac AngiographyInterventions, Jg. 93 (2018-01-12), Heft 2
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Zugriff:
Objectives This prospective, observational all-comers registry assessed the safety and efficacy of a Drug Coated Balloon-only strategy (DCB-only) in patients with coronary lesions. Background Data regarding the performance of a DCB-only approach, especially in patients with previously untreated de-novo coronary artery disease (CAD), are still limited. Methods This study was conducted as an international, multicenter registry primarily enrolling patients with de-novo CAD. However, it was also possible to include patients with in-stent restenosis (ISR). The primary endpoint was the rate of clinically driven target lesion revascularization (TLR) after 9 months. Results A total of 1,025 patients with a mean age of 64.0 ± 11.2 years were enrolled. The majority of treated lesions were de-novo (66.9%), followed by drug-eluting-stent ISR (DES-ISR; 22.6%) and bare-metal-stent ISR (BMS-ISR; 10.5%). The TLR rate was lower in the de-novo group (2.3%) when compared to BMS- (2.9%) and DES-ISR (5.8%) (P = 0.049). Regarding MACE, there was a trend toward fewer events in the de-novo group (5.6%) than in the BMS- (7.8%) and DES-ISR cohort (9.6%) (P = 0.131). Subgroup analyses revealed that lesion type (95% CI 1.127-6.587); P = 0.026) and additional stent implantation (95% CI 0.054-0.464; P = 0.001) were associated with higher TLR rates. Conclusions Our results show that DCB-only angioplasty of de-novo coronary lesions is associated with low MACE and TLR rates. Thus, DCBs appear to be an attractive alternative for the interventional, stentless treatment of suitable de-novo coronary lesions.
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Prospective, large-scale multicenter trial for the use of drug-coated balloons in coronary lesions: The DCB-only All-Comers Registry
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Autor/in / Beteiligte Person: | Amin Ariff Nuruddin ; Caramanno, Giuseppe ; Frey, Norbert ; Poyet, Raphael ; Aubry, Pierre ; Chin, Kenneth ; Wan Azman Wan Ahmad ; Houng Bang Liew ; Maskon, Oteh ; Milazzo, Diego ; Waliszewski, Matthias ; Rosenberg, Mark |
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Zeitschrift: | Catheterization and cardiovascular interventions : official journal of the Society for Cardiac AngiographyInterventions, Jg. 93 (2018-01-12), Heft 2 |
Veröffentlichung: | 2018 |
Medientyp: | unknown |
ISSN: | 1522-726X (print) |
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