Five-Year Results of the Preoperative Accelerated Partial Breast Irradiation (PAPBI) Trial
In: International journal of radiation oncology, biology, physics, Jg. 106 (2019-09-02), Heft 5
Online
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Zugriff:
Purpose In this multicenter phase 2 feasibility study, we investigated the impact of preoperative accelerated partial breast irradiation (PAPBI) on local control, breast fibrosis, and cosmetic outcome. Methods and Materials Women aged >60 years with an invasive, unifocal (mammography and magnetic resonance imaging), nonlobular adenocarcinoma of the breast were treated with PAPBI. Six weeks after radiation therapy, a wide local excision was performed. Radiation therapy consisted of 10 × 4 Gy (2010-2013) or 5 × 6 Gy (after 2013) to the tumor (gross target volume) with a 25 mm margin (20 mm from gross target volume to clinical target volume, 5 mm planning target volume). Results One hundred thirty-three patients treated between 2010 and 2016 were analyzed with a median follow-up of 5.0 years (0.9-8.8 years). Seventy-eight (59%) patients were treated with 10 × 4 Gy in 2 weeks and 55 (41%) patients with 5 × 6 Gy in 1 week. Eighteen postoperative complications (14%) occurred in 15 patients (11%). The proportion of patients with no to mild fibrosis in the treated part of the breast at 2 years and later time points was around 90%. Cosmesis improved over time in several patients: excellent to good cosmetic score as rated by the physician was 68% at 6 months and 92% at 5 years. Seventy-seven percent (6 months) to 82% (5 years) of patients were “satisfied” or “very satisfied” with their cosmetic outcome. Three recurrences were detected in the biopsy track and 1 recurrence in the ipsilateral breast. Conclusions PAPBI is a feasible method with a low postoperative complication rate, limited fibrosis, and good to excellent cosmetic outcome. The local recurrence rate was 3% at 5 years; however, no local recurrences were observed since removal of the needle biopsy track.
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Five-Year Results of the Preoperative Accelerated Partial Breast Irradiation (PAPBI) Trial
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Autor/in / Beteiligte Person: | Femke van der Leij ; Marc J. van de Vijver ; Foukakis, Theodoros ; Wesseling, Jelle ; Loo, Claudette E. ; Paula H.M. Elkhuizen ; Lekberg, Tobias ; Desirée H.J.G. van den Bongard ; Bourgier, Céline ; Michiel de Maaker ; Sophie C.J. Bosma ; Bartelink, Harry ; Scholten, A.N. ; Vreeswijk, S. ; Rivera, Sofia ; Emiel J. Th. Rutgers ; Auzac, G. ; Pathology |
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Zeitschrift: | International journal of radiation oncology, biology, physics, Jg. 106 (2019-09-02), Heft 5 |
Veröffentlichung: | 2019 |
Medientyp: | unknown |
ISSN: | 1879-355X (print) ; 0360-3016 (print) |
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