Development and applicability of an in vitro digestion model in assessing the bioaccessibility of contaminants from food
Rijksinstituut voor Volksgezondheid en Milieu RIVM, 2007
Online
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Zugriff:
Food is considered a major source for exposure to many contaminants. Only the fraction of the contaminant that is released from the food (bioaccessible) and is bioavailable (concentration in blood, organ and tissues) can exert toxic effects. The oral bioavailability of compounds is dependent on the food product, food processing or food preparation. This hampers an accurate risk assessment of ingested toxic compounds in humans. This report documents the development of an in vitro digestion model allowing for measurement of the bioaccessibility of ingested contaminants from food as an indicator of oral bioavailability. The applicability of the in vitro digestion model was investigated in 4 food products containing the following contaminants: cadmium in lettuce and radish, aflatoxin B1 in peanuts and ochratoxin A in buckwheat. The bioaccessibility of contaminants from food and other ingested matrices could be determined reproducibly, was dependent on its matrix and could be affected by the experimental conditions applied in the in vitro digestion model, e.g. simulating fasted or fed conditions. Not all the contaminants were released from their matrices during digestion, indicating that internal exposure to the contaminant was lower than the external exposure. The results of the (pre)validation of the in vitro digestion model with adsorbents and bioaccessibility of aflatoxin B1 and ochratoxin A, show the in vitro digestion model as a possible powerful tool in predicting in vivo bioavailability of compounds.
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Development and applicability of an in vitro digestion model in assessing the bioaccessibility of contaminants from food
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Autor/in / Beteiligte Person: | Versantvoort, CHM ; Kamp E van de ; Rompelberg, CJM ; SIR |
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Veröffentlichung: | Rijksinstituut voor Volksgezondheid en Milieu RIVM, 2007 |
Medientyp: | unknown |
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