Short high fat diet triggers reversible and region specific effects in DCX
In: Scientific reports, Jg. 11 (2021-03-23), Heft 1
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Zugriff:
Adolescence represents a crucial period for maturation of brain structures involved in cognition. Early in life unhealthy dietary patterns are associated with inferior cognitive outcomes at later ages; conversely, healthy diet is associated with better cognitive results. In this study we analyzed the effects of a short period of hypercaloric diet on newborn hippocampal doublecortin+ (DCX) immature neurons in adolescent mice. Male mice received high fat diet (HFD) or control low fat diet (LFD) from the 5th week of age for 1 or 2 weeks, or 1 week HFD followed by 1 week LFD. After diet supply, mice were either perfused for immunohistochemical (IHC) analysis or their hippocampi were dissected for biochemical assays. Detailed morphometric analysis was performed in DCX+ cells that displayed features of immature neurons. We report that 1 week-HFD was sufficient to dramatically reduce dendritic tree complexity of DCX+ cells. This effect occurred specifically in dorsal and not ventral hippocampus and correlated with reduced BDNF expression levels in dorsal hippocampus. Both structural and biochemical changes were reversed by a return to LFD. Altogether these studies increase our current knowledge on potential consequences of hypercaloric diet on brain and in particular on dorsal hippocampal neuroplasticity.
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Short high fat diet triggers reversible and region specific effects in DCX
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Autor/in / Beteiligte Person: | Fausto, Chiazza ; Heather, Bondi ; Irene, Masante ; Federico, Ugazio ; Valeria, Bortolotto ; Pier Luigi, Canonico ; Mariagrazia, Grilli |
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Zeitschrift: | Scientific reports, Jg. 11 (2021-03-23), Heft 1 |
Veröffentlichung: | 2021 |
Medientyp: | unknown |
ISSN: | 2045-2322 (print) |
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