Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency
In: Nature, Jg. 588 (2020-02-06), Heft 7836
Online
unknown
Zugriff:
Cancer therapies that target epigenetic repressors can mediate their effects by activating retroelements within the human genome. Retroelement transcripts can form double-stranded RNA (dsRNA) that activates the MDA5 pattern recognition receptor
Titel: |
Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency
|
---|---|
Autor/in / Beteiligte Person: | Parinaz, Mehdipour ; Sajid A, Marhon ; Ilias, Ettayebi ; Ankur, Chakravarthy ; Amir, Hosseini ; Yadong, Wang ; Fabíola Attié, de Castro ; Helen, Loo Yau ; Charles, Ishak ; Sagi, Abelson ; Catherine A, O'Brien ; Daniel D, De Carvalho |
Link: | |
Zeitschrift: | Nature, Jg. 588 (2020-02-06), Heft 7836 |
Veröffentlichung: | 2020 |
Medientyp: | unknown |
ISSN: | 1476-4687 (print) |
Schlagwort: |
|
Sonstiges: |
|