The effect of lithium chloride treatment on cell-mediated immunity in mice
In: Folia biologica, Jg. 39 (1991), Heft 1-4
Online
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Zugriff:
The immunomodulatory effect of lithium chloride (LiCl) administered i.p. to adult mice (150 mg/kg/day) on cellular immunity in vivo was investigated. A short (6-day) treatment with LiCl of either spleen cell donors in semiallogeneic or xenogeneic GVH reaction, or recipients in semiallogeneic HVG reaction, significantly diminished the early sings of local cell-mediated immunity. A short-term LiCl treatment of donor mice also abrogated systemic GVH reaction in newborn F1 recipients, while a treatment prolonged for 20 days did not alter the high GVH response of spleen cells typical for untreated donors. Thus, a striking time-dependent efficacy of LiCl on the reduction of GVH reaction was found.
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The effect of lithium chloride treatment on cell-mediated immunity in mice
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Autor/in / Beteiligte Person: | M, Bubak-Satora ; A, Skowron-Cendrzak ; M, Kubera |
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Zeitschrift: | Folia biologica, Jg. 39 (1991), Heft 1-4 |
Veröffentlichung: | 1991 |
Medientyp: | unknown |
ISSN: | 0015-5497 (print) |
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