Alternatively spliced ltk mRNA in neurons predicts a receptor with a larger putative extracellular domain
In: Oncogene, Jg. 6 (1991-12-01), Heft 12
Online
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Zugriff:
Ltk is a new member of the ros/insulin receptor family of tyrosine kinases that is expressed in murine B-lymphocyte precursors and forebrain neurons. We previously reported that lymphoid ltk cDNAs predict a 69 kDa transmembrane glycoprotein, which uses a CUG translational start codon and has a 110 amino acid putative extracellular domain. We now show that the predominant ltk mRNA in brain is alternatively spliced and predicts a protein with a substantially larger extracellular part. The human ltk gene maps to chromosome 15, bands q13-21, a region containing the breakpoint of a recurring chromosomal abnormality in B-cell non-Hodgkin lymphomas.
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Alternatively spliced ltk mRNA in neurons predicts a receptor with a larger putative extracellular domain
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Autor/in / Beteiligte Person: | V H, Haase ; A J, Snijders ; S M, Cooke ; M N, Teng ; D, Kaul ; M M, Le Beau ; G A, Bruns ; A, Bernards |
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Zeitschrift: | Oncogene, Jg. 6 (1991-12-01), Heft 12 |
Veröffentlichung: | 1991 |
Medientyp: | unknown |
ISSN: | 0950-9232 (print) |
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