Rac-ing to the plasma membrane
In: Small GTPases, Jg. 3 (2012), Heft 1, S. 60-66
Online
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Zugriff:
The functional cycle of the Rac1 GTPase involves a large number of steps, including post-translational processing, cytosolic sequestration by RhoGDIs, translocation to specific subcellular localizations, activation by GDP/GTP exchange, inactivation by GTP hydrolysis, and re-formation of cytosolic Rac1/RhoGDI inhibitory complexes. Here, we summarize the current knowledge about the regulation of those steps. In addition, we discuss a recently described, cytoskeletal-dependent feed-back loop that favors the efficient translocation and activation of Rac subfamily proteins during cell signaling. This route is mediated by a heteromolecular protein complex composed of the cytoskeletal protein coronin1A, the Dbl family member ArhGEF7, the serine/threonine kinase Pak1, and the Rac1/RhoGDI dimer. This route promotes the translocation of Rac1/RhoGDI to F-actin-rich juxtamembrane areas, the Pak1-dependent release of Rac1 from the Rac1/RhoGDI complex, and Rac1 activation. This pathway is important for optimal Rac1 activation during the signaling of the EGF receptor, integrins, and the antigenic T-cell receptor.
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Rac-ing to the plasma membrane
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Autor/in / Beteiligte Person: | Bustelo, Xosé R. ; Ojeda, Virginia ; Barreira, María ; Sauzeau, Vincent ; Castro-Castro, Antonio |
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Zeitschrift: | Small GTPases, Jg. 3 (2012), Heft 1, S. 60-66 |
Veröffentlichung: | Landes Bioscience, 2012 |
Medientyp: | unknown |
ISSN: | 2154-1256 (print) ; 2154-1248 (print) |
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