Three new dihydrochalcones from the leaves of Artocarpus sericicarpus Jarrett and their activity against Plasmodium falciparum ...
Taylor & Francis, 2024
academicJournal
Zugriff:
Three new dihydrochalcones: artoserichalcone A-C ( 1-3 ), were isolated from the leaves of Artocarpus sericicarpus . The structures of compounds were determined based on NMR spectrum ( 1 H, 13 C, and 2D) and HRESIMS spectroscopic analysis. Compounds ( 1 ) and ( 3 ) showed active antimalarial activity with IC 50 values of 16.90 and 13.56 µM, respectively. Meanwhile, compound ( 2 ) with an IC 50 value of 63.01 µM was categorised as a moderate antimalarial substance. The cytotoxicity against Huh7, HepG2, BHK-21, and Vero cells showed that compounds ( 1-3 ) with CC 50 values > 20 µg/mL could be considered non-cytotoxic. Compounds ( 1-3 ) exhibited antimalarial activity against Plasmodium falciparum and non-toxic as an antimalarial agent. ...
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Three new dihydrochalcones from the leaves of Artocarpus sericicarpus Jarrett and their activity against Plasmodium falciparum ...
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Autor/in / Beteiligte Person: | Tumewu, Lidya ; Ilmi, Hilkatul ; Sari, Defi Kartika ; Permanasari, Adita Ayu ; Nisa, Hanifah Khairun ; Saputri, Ratih Dewi ; Tjahjandarie, Tjitjik Srie ; Tanjung, Mulyadi ; Osman, Che Puteh ; Ismail, Nor Hadiani ; Suciati ; Widyawaruyanti, Aty ; Hafid, Achmad Fuad |
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Veröffentlichung: | Taylor & Francis, 2024 |
Medientyp: | academicJournal |
DOI: | 10.6084/m9.figshare.25127584.v1 |
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