基因ARHI在胃癌MKN细胞株中抑癌作用及相关细胞信号传导通路探讨 ; Study for roles of the ARHI gene on gastric cancer MKN cells and involved signaling pathway

ARHI（AplysiarashomologI）是由YU等在1999年从人卵巢和乳腺上皮细胞及其癌细胞中克隆并命名，定位于人染色体1p31，全长8kb，包含2个外显子，一个内含子，编码26-KD的GTP结合蛋白。ARHI是一种单等位基因表达和母源性印迹的基因，它在肿瘤细胞中表达异常从而抑制肿瘤细胞的生长、运动和侵袭。核转录因子（nuclearfactor-κB）是1986年Sen和Baltimore首先于B淋巴细胞核抽提物中发现的一种结合于免疫球蛋白κ轻链增强子上的核蛋白。文献报道，NF-κB通过对相应基因的转录调节促进肿瘤的发生、肿瘤细胞的增殖、侵袭和转移。NF-κB特别是RelA（P65）. ; ARHI（ Ras homolog member I ） was first identified from ovarian and breast cancers cell by Yu at 1999. The ARHI gene maps to a locus on human chromosome 1p31, spans approximately 8 kb containing two exons and one intron, encodes a 26‐kDa protein.ARHI is a maternally imprinted and monoallelic expressed tumor suppressor gene, the expression of which is abnormal in many cancers and inhabit the cancer . ; 学位：医学硕士 ; 院系专业：医学院临床医学系_内科学 ; 学号：24520081153443