Structure and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in Human Disease
In: The FASEB Journal ; volume 33, issue S1 ; ISSN 0892-6638 1530-6860, 2019
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Zugriff:
Recent exome‐ and genome‐wide sequencing studies in human cancer have unmasked a striking frequency of mutations in the genes encoding subunits of the mammalian SWI/SNF (mSWI/SNF) family of ATP‐dependent chromatin remodeling complexes. Our laboratory uses biochemistry, structural biology, systems biology, and functional genomics‐based approaches to define the mechanisms of chromatin and gene regulation carried out by the mSWI/SNF family of regulators. Using a collection of approaches, we recently defined the architecture and assembly pathway across three mSWI/SNF complex classes: canonical BAF, PBAF, and a newly‐defined complex, ncBAF, and defined the requirements of each subunit for complex formation and stability. In addition, we have studied rare, genetically well‐defined pediatric cancers including synovial sarcoma, Ewing sarcoma, malignant rhabdoid tumor and others, all of which involve BAF complex perturbations as critical drivers of their oncogenic programs. These studies have informed the diverse mechanisms underlying mSWI/SNF complex targeting and function and have provided new foundations for therapeutic development. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
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Structure and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in Human Disease
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Autor/in / Beteiligte Person: | Kadoch, Cigall |
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Zeitschrift: | The FASEB Journal ; volume 33, issue S1 ; ISSN 0892-6638 1530-6860, 2019 |
Veröffentlichung: | Wiley, 2019 |
Medientyp: | academicJournal |
DOI: | 10.1096/fasebj.2019.33.1_supplement.92.1 |
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