E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium
In: NHMRC/400281; NHMRC/400413; pii: 10.1038/s41598-018-23733-4; Horne, H. N., Oh, 2018
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Zugriff:
E-cadherin (CDH1) is a putative tumor suppressor gene implicated in breast carcinogenesis. Yet, whether risk factors or survival differ by E-cadherin tumor expression is unclear. We evaluated E-cadherin tumor immunohistochemistry expression using tissue microarrays of 5,933 female invasive breast cancers from 12 studies from the Breast Cancer Consortium. H-scores were calculated and case-case odds ratios (OR) and 95% confidence intervals (CIs) were estimated using logistic regression. Survival analyses were performed using Cox regression models. All analyses were stratified by estrogen receptor (ER) status and histologic subtype. E-cadherin low cases (N = 1191, 20%) were more frequently of lobular histology, low grade, >2 cm, and HER2-negative. Loss of E-cadherin expression (score < 100) was associated with menopausal hormone use among ER-positive tumors (ever compared to never users, OR = 1.24, 95% CI = 0.97-1.59), which was stronger when we evaluated complete loss of E-cadherin (i.e. H-score = 0), OR = 1.57, 95% CI = 1.06-2.33. Breast cancer specific mortality was unrelated to E-cadherin expression in multivariable models. E-cadherin low expression is associated with lobular histology, tumor characteristics and menopausal hormone use, with no evidence of an association with breast cancer specific survival. These data support loss of E-cadherin expression as an important marker of tumor subtypes.
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E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium
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Autor/in / Beteiligte Person: | Horne, HN ; Oh, H ; Sherman, ME ; Palakal, M ; Hewitt, SM ; Schmidt, MK ; Milne, RL ; Hardisson, D ; Benitez, J ; Blomqvist, C ; Bolla, MK ; Brenner, H ; Chang-Claude, J ; Cora, R ; Couch, FJ ; Cuk, K ; Devilee, P ; Easton, DF ; Eccles, DM ; Eilber, U ; Hartikainen, JM ; Heikkila, P ; Holleczek, B ; Hooning, MJ ; Jones, M ; Keeman, R ; Mannermaa, A ; Martens, JWM ; Muranen, TA ; Nevanlinna, H ; Olson, JE ; Orr, N ; Perez, JIA ; Pharoah, PDP ; Ruddy, KJ ; Saum, K-U ; Schoemaker, MJ ; Seynaeve, C ; Sironen, R ; Smit, VTHBM ; Swerdlow, AJ ; Tengstrom, M ; Thomas, AS ; Timmermans, AM ; Tollenaar, RAEM ; Troester, MA ; van Asperen, CJ ; van Deurzen, CHM ; Van Leeuwen, FF ; Van'tVeer, LJ ; Garcia-Closas, M ; Figueroa, JD |
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Zeitschrift: | NHMRC/400281; NHMRC/400413; pii: 10.1038/s41598-018-23733-4; Horne, H. N., Oh, 2018 |
Veröffentlichung: | NATURE PUBLISHING GROUP, 2018 |
Medientyp: | academicJournal |
ISSN: | 2045-2322 (print) |
DOI: | 10.1038/s41598-018-23733-4. |
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