Myelin replacement triggered by single-cell demyelination in mouse cortex
In: ISSN: 2041-1723, 2020
Online
academicJournal
Zugriff:
International audience ; Myelin, rather than being a static insulator of axons, is emerging as an active participant in circuit plasticity. This requires precise regulation of oligodendrocyte numbers and myelina-tion patterns. Here, by devising a laser ablation approach of single oligodendrocytes, followed by in vivo imaging and correlated ultrastructural reconstructions, we report that in mouse cortex demyelination as subtle as the loss of a single oligodendrocyte can trigger robust cell replacement and remyelination timed by myelin breakdown. This results in reliable rees-tablishment of the original myelin pattern along continuously myelinated axons, while in parallel, patchy isolated internodes emerge on previously unmyelinated axons. Therefore, in mammalian cortex, internodes along partially myelinated cortical axons are typically not reestablished, suggesting that the cues that guide patchy myelination are not preserved through cycles of de-and remyelination. In contrast, myelin sheaths forming continuous patterns show remarkable homeostatic resilience and remyelinate with single axon precision.
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Myelin replacement triggered by single-cell demyelination in mouse cortex
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Autor/in / Beteiligte Person: | Snaidero, Nicolas ; Schifferer, Martina ; Mezydlo, Aleksandra ; Zalc, Bernard ; Kerschensteiner, Martin ; Misgeld, Thomas ; Biomedical Center = Biomedizinisches centrum Munich, Germany (BMC) ; Ludwig Maximilian University Munich = Ludwig Maximilians Universität München (LMU) ; German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) ; Technische Universität Munchen - Technical University Munich - Université Technique de Munich (TUM) ; Munich Cluster for systems neurology Munich (SyNergy) ; Technische Universität Munchen - Technical University Munich - Université Technique de Munich (TUM)-Ludwig Maximilian University Munich = Ludwig Maximilians Universität München (LMU) ; Institute of Clinical Neuroimmunology Munich, Germany ; Institut du Cerveau = Paris Brain Institute (ICM) ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière AP-HP ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS) |
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Zeitschrift: | ISSN: 2041-1723, 2020 |
Veröffentlichung: | HAL CCSD ; Nature Publishing Group, 2020 |
Medientyp: | academicJournal |
DOI: | 10.1038/s41467-020-18632-0 |
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