Infections rapportées chez 109 patients avec syndrome de Gougerot-Sjögren primaire suivis au CHU de Montpellier
In: ISSN: 0248-8663, 2022
Online
academicJournal
Zugriff:
International audience ; Introduction: Infections are responsible for a part of the overall mortality in primary Sjögren's syndrome patients (pSS). Our retrospective monocentric study aimed at describing infections reported in a population of pSS hospitalized patients, along with the characteristics of their disease.Methods: Patients with SS have been randomly selected from our hospital database claim, between 2009 and 2018. After careful analysis of their medical chart, only patients with pSS and fulfilling ACR/EULAR 2016 diagnosis criteria were included. We collected main clinical, biological and pathological characteristics of SS, along with all the reported infections during the follow-up. The characteristics of the disease were compared according to the presence of an infection in hospitalization.Results: In total, 109 pSS patients were included (93% of women, mean age 53.6±14.3 years, mean follow-up 8.2±8.4 years). Fifty-one percent had been exposed to hydroxychloroquine (HCQ). Seventy-eight infections were recorded in 47 (43%) patients. Twenty-five infections were recorded in hospitalization (5 in critical care) in 20 (18%) patients, whom leading causes were urinary tract (28%), pulmonary (24%), ENT (16%), and intestinal (12%) infections. pSS patients with infections in hospitalization were older, exhibited more hypocomplementemia, and were less exposed to HCQ. We found no difference in immunosuppressive treatments exposure.Conclusions: The impact of HCQ exposure on infectious risk needs further investigations. Broad vaccination campaign and tight control of sicca syndrome could lead to a better control of infection risk.
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Infections rapportées chez 109 patients avec syndrome de Gougerot-Sjögren primaire suivis au CHU de Montpellier
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Autor/in / Beteiligte Person: | Henry, Kim ; Deligny, Christophe N. ; Witkowski Durand Viel, Philine ; Morel, Jacques ; Guilpain, Philippe ; Goulabchand, Radjiv ; Hôpital Saint Eloi (CHRU Montpellier) ; Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier) ; Hôpital Pierre Zobda-Quitman CHU de la Martinique ; CHU de la Martinique Fort de France ; Physiologie & médecine expérimentale du Cœur et des Muscles U 1046 (PhyMedExp) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM) ; Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB) ; Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM) ; Centre Hospitalier Universitaire de Nîmes (CHU Nîmes) |
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Zeitschrift: | ISSN: 0248-8663, 2022 |
Veröffentlichung: | HAL CCSD ; Elsevier, 2022 |
Medientyp: | academicJournal |
DOI: | 10.1016/j.revmed.2022.08.010 |
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