Stealth virus remains oncolytic in the presence of MeV-immune serum.
2021
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Zugriff:
(A) SKOV3ip.Fluc cells were injected into athymic nude mice and allowed to establish for 10 days. Next, mice in the relevant groups received 600 mIU of anti-MeV IgG antibody intraperitoneally three hours before virus treatment via the same route. (B) Kaplan-Meier survival curves (n = 5 mice per group). Significant differences among the groups were determined by the long-rank test (ns, not significant; *, p<0.05; **, p<0.002). (C) Representative BLI showing the dorsal view of treated animals. Radiance (photons per second per cm per steradian, p/s/cm 2 /sr) was translated to colors to indicate tumor burden in the mice, according to the legend shown on the right. (D) Quantification of the total body luminescence in photons per second per cm per steradian (p/s/cm 2 /sr). n = 5. Statistical significance was determined by one-way ANOVA with Dunnetts’ multiple comparison test. Ns, no significant; nd, not done.
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Stealth virus remains oncolytic in the presence of MeV-immune serum.
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Autor/in / Beteiligte Person: | Miguel Ángel Muñoz-Alía (4872121) ; Rebecca A. Nace (10090917) ; Alexander Tischer (2929434) ; Lianwen Zhang (582471) ; Eugene S. Bah (10090920) ; Matthew Auton (1942864) ; Stephen J. Russell (106169) |
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Veröffentlichung: | 2021 |
Medientyp: | Bild |
DOI: | 10.1371/journal.ppat.1009283.g007 |
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