One-Pot Synthesis of Unprotected 2‑Acylpyrroles from 1,2,3 - Triazoles and 2‑Hydroxymethylallyl Carbonates
2022
unknown
Zugriff:
An efficient, tandem one-pot approach to synthesize multisubstituted 2-acylpyrroles from readily prepared N -tosyl triazoles and 2-hydroxymethylallyl carbonates is reported. The reaction proceeds via Rh(II)-catalyzed O–H insertion, [3,3]-sigmatropic rearrangement, Pd(0)-catalyzed oxidative addition, intramolecular cyclization, DBU-promoted E1cB elimination, double bond isomerization, and aromatization, enabling the disconnection and formation of multiple bonds in one reactor. The approach represents a highly regioselective way to access di-, tri-, and tetra-substituted N H pyrroles with high efficiency.
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One-Pot Synthesis of Unprotected 2‑Acylpyrroles from 1,2,3 - Triazoles and 2‑Hydroxymethylallyl Carbonates
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Autor/in / Beteiligte Person: | Jong-Un Park (8072564) ; Liang-Zhu Huang (2855771) ; Ho-Jun Cho (14216167) ; Boyoung Y. Park (2065717) ; Ju Hyun Kim (14430) |
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Veröffentlichung: | 2022 |
Medientyp: | unknown |
DOI: | 10.1021/acs.joc.2c02602.s002 |
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