IGOB 131TM) Extract in Leptin-deficient Obese Mice
In: http://ocean.kisti.re.kr/downfile/volume/kfn/SPOOBG/2014/v43n10/SPOOBG_2014_v43n10_1477.pdf
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Zugriff:
This study investigated the anti-obesity effects of African mango (Irvingia gabonesis, IGOB 131TM) extract in leptin-deficient obese mice. Experimental groups were treated with two different doses of IGOB 131TM (1 % and 2 % in each AIN93G supplement) for 8 weeks. Treatment of obese mice with both low and high dose of IGOB 131TM significantly reduced body weight gain by 10.9 % and 13.3%, respectively, compared to control obese mice. Subcutaneous adipose tissue weight of mice was significantly reduced by 18 % by low-dose and 23 % by high-dose supplementation. This result was supported by micro-CT analysis around the abdominal regions of mice, indicating that the adipose tissue area and volume were significantly reduced by treatment with IGOB 131TM. Serum levels of triglycerides in the low- and high-dose groups were reduced by 36.5 % and 43.8%, respectively, upon treatment with IGOB 131TM, whereas total cholesterol levels were reduced by 31.8 % and 35.4%. Interestingly, the serum LDL level decreased upon treatment with IGOB 131TM while the serum level of HDL dramatically increased upon high-dose treatment with IGOB 131TM, resulting in a significant reduction in the LDL to HDL ratio of 59.2%. These results were supported by the expression levels of enzymes and proteins related to lipid metabolism assessed by real-time PCR. There was a significant increase of in adiponectin expression as well as significant decreases in the expression of FAS, LPL, and lipid regulatory transcription factors such as PPAR-γ, C/EBP, and SREBP upon both low- and high-dose IGOB 131TM treatment. However, there was no statistical difference between low- and high-dose treatments.
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IGOB 131TM) Extract in Leptin-deficient Obese Mice
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Autor/in / Beteiligte Person: | Lee, Minhee ; Nam, Da-eun ; Ok Kyung Kim ; Tae Jin Shim ; Ji Hoon Kim ; Lee, Jeongmin ; The Pennsylvania State University CiteSeerX Archives |
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Zeitschrift: | http://ocean.kisti.re.kr/downfile/volume/kfn/SPOOBG/2014/v43n10/SPOOBG_2014_v43n10_1477.pdf |
Medientyp: | academicJournal |
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