Clinical features and comorbidity pattern of HCV infected migrants compared to native patients in care in Italy: A real-life evaluation of the PITER cohort
In: DIGESTIVE AND LIVER DISEASE, 2021, Heft 12, S. 1603-1609
Online
academicJournal
Zugriff:
Background: Direct-acting antivirals are highly effective for the treatment of hepatitis C virus (HCV) infection, regardless race/ethnicity. We aimed to evaluate demographic, virological and clinical data of HCV-infected migrants vs. natives consecutively enrolled in the PITER cohort. Methods: Migrants were defined by country of birth and nationality that was different from Italy. Mann-Whitney U test, Chi-squared test and multiple logistic regression were used. Results: Of 10,669 enrolled patients, 301 (2.8%) were migrants: median age 47 vs. 62 years, (p < 0.001), females 56.5% vs. 45.3%, (p < 0.001), HBsAg positivity 3.8% vs. 1.4%, (p < 0.05). Genotype 1b was prevalent in both groups, whereas genotype 4 was more prevalent in migrants (p < 0.05). Liver disease severity and sustained virologic response (SVR) were similar. A higher prevalence of comorbidities was reported for natives compared to migrants (p < 0.05). Liver disease progression cofactors (HBsAg, HIV coinfection, alcohol abuse, potential metabolic syndrome) were present in 39.1% and 47.1% (p > 0.05) of migrants and natives who eradicated HCV, respectively. Conclusion: Compared to natives, HCV-infected migrants in care have different demographics, HCV genotypes, viral coinfections and comorbidities and similar disease severity, SVR and cofactors for disease progression after HCV eradication. A periodic clinical assessment after HCV eradication in Italians and migrants with cofactors for disease progression is warranted.
Titel: |
Clinical features and comorbidity pattern of HCV infected migrants compared to native patients in care in Italy: A real-life evaluation of the PITER cohort
|
---|---|
Autor/in / Beteiligte Person: | Quaranta, M. G. ; Ferrigno, L. ; Tata, X. ; D'Angelo, F. ; Massari, M. ; Coppola, C. ; Biliotti, E. ; Giorgini, A. ; Laccabue, D. ; Ciancio, A. ; Blanc, P. L. ; Margotti, M. ; Ieluzzi, D. ; Brunetto, M. R. ; Barbaro, F. ; Russo, F. P. ; Beretta, I. ; Morsica, G. ; Verucchi, G. ; Saracino, A. ; Galli, M. ; Kondili, L. A. ; Mazzaro, C. ; Bertola, M. ; Benedetti, A. ; Schiada, L. ; Cucco, M. ; Giacometti, A. ; Brescini, L. ; Castelletti, S. ; Fiorentini, A. ; Angarano, G. ; Milella, M. ; Leo, A. D. ; Rendina, M. ; Salvatore D'ABRAMO F. ; Lillo, C. ; Iannone, A. ; Piazzolla, M. ; Badia, L. ; Piscaglia, F. ; Benevento, F. ; Serio, I. ; Castelli, F. ; Zaltron, S. ; Spinetti, A. ; Odolini, S. ; Bruno, R. ; Mondelli, M. ; Chessa, L. ; Loi, M. ; Torti, C. ; Costa, C. ; Mazzitelli, M. ; Pisani, V. ; Scaglione, V. ; Trecarichi, E. M. ; Zignego, A. L. ; Monti, M. ; Madia, F. ; Attala, L. ; Pierotti, P. ; Salomoni, E. ; Mariabelli, E. ; Santantonio, T. A. ; Bruno, S. R. ; Cela, E. M. ; Bassetti, M. ; Mazzarello, G. ; Alessandrini, A. I. ; Biagio, A. D. ; Nicolini, L. A. ; Raimondo, G. ; Filomia, R. ; Aghemo, A. ; Meli, R. ; Lazzarin, A. ; Salpietro, S. ; Fracanzani, A. L. ; Fatta, E. ; Lombardi, R. ; Lampertico, P. ; Borghi, M. ; D'ambrosio, R. ; Degasperi, E. ; Puoti, M. ; Baiguera, C. ; D'AMICO, F. ; Vinci, M. ; Rumi, M. G. ; Zuin, M. ; Zermiani, P. ; Andreone, P. ; Caraceni, P. ; Guarneri, V. ; Villa, E. ; Bernabucci, V. ; Bristot, L. ; Paradiso, M. L. ; Migliorino, G. ; Gambaro, A. ; Lapadula, G. ; Spolti, A. ; Soria, A. ; Invernizzi, P. ; Ciaccio, A. ; LucA, M. ; Malinverno, F. ; Ratti, L. ; Amoruso, D. C. ; Pisano, F. ; Scarano, F. ; Staiano, L. ; Morisco, F. ; Cossiga, V. ; Gentile, I. ; Buonomo, A. R. ; Foggia, M. ; Zappulo, E. ; Federico, A. ; Dallio, M. ; Coppola, N. ; Sagnelli, C. ; Martini, S. ; Monari, C. ; Nardone, G. ; Sgamato, C. ; Chemello, L. ; Cavalletto, L. ; Sterrantino, D. ; Zanetto, A. ; Zanaga, P. ; Brancaccio, G. ; Craxi, A. ; Petta, S. ; Calvaruso, V. ; Crapanzano, L. ; Madonia, S. ; Cannizzaro, M. ; Bruno, E. M. ; Licata, A. ; Amodeo, S. ; Capitano, A. R. ; Ferrari, C. ; Negri, E. ; Orlandini, A. ; Pesci, M. ; Gulminetti, R. ; Pagnucco, L. ; Parruti, G. ; Stefano, P. D. ; Coco, B. ; Corsini, R. ; Garlassi, E. ; Andreoni, M. ; Teti, E. ; Cerva, C. ; Baiocchi, L. ; Grassi, G. ; Gasbarrini, A. ; Pompili, M. ; Siena, M. D. ; Taliani, G. ; Spaziante, M. ; Persico, M. ; Masarone, M. ; Aglitti, A. ; Calvanese, G. ; Anselmo, M. ; Leo, P. D. ; Marturano, M. ; Saracco, G. M. ; M.G., Quaranta ; P.L., Blanc ; M.R., Brunetto ; F.P., Russo ; L.A., Kondili ; A.D., Leo ; E.M., Trecarichi ; A.L., Zignego ; T.A., Santantonio ; S.R., Bruno ; E.M., Cela ; A.I., Alessandrini ; A.D., Biagio ; L.A., Nicolini ; A.L., Fracanzani ; M.G., Rumi ; M.L., Paradiso |
Link: | |
Zeitschrift: | DIGESTIVE AND LIVER DISEASE, 2021, Heft 12, S. 1603-1609 |
Veröffentlichung: | Elsevier B.V., 2021 |
Medientyp: | academicJournal |
DOI: | 10.1016/j.dld.2021.03.020 |
Schlagwort: |
|
Sonstiges: |
|