Pituitary MRI Features in Acromegaly Resulting From Ectopic GHRH Secretion From a Neuroendocrine Tumor: Analysis of 30 Cases
In: ISSN: 0021-972X, 2023
Online
academicJournal
Zugriff:
International audience ; Context: Ectopic acromegaly is a consequence of rare neuroendocrine tumors (NETs) that secrete GHRH. This abnormal GHRH secretion drives GH and IGF-1 excess, with a clinical presentation similar to classical pituitary acromegaly. Identifying the underlying cause for the GH hypersecretion in the setting of ectopic GHRH excess is, however, essential for proper management both of acromegaly and the NET. Owing to the rarity of NETs, the imaging characteristics of the pituitary in ectopic acromegaly have not been analyzed in depth in a large series.Objective: Characterize pituitary magnetic resonance imaging (MRI) features at baseline and after NET treatment in patients with ectopic acromegaly.Design: Multicenter, international, retrospective.Setting: Tertiary referral pituitary centers.Patients: Thirty ectopic acromegaly patients having GHRH hypersecretion.Intervention: None.Main outcome measure: MRI characteristics of pituitary gland, particularly T2-weighted signal.Results: In 30 patients with ectopic GHRH-induced acromegaly, we found that most patients had hyperplastic pituitaries. Hyperplasia was usually moderate but was occasionally subtle, with only small volume increases compared with normal ranges for age and sex. T2-weighted signal was hypointense in most patients, especially in those with hyperplastic pituitaries. After treatment of the NET, pituitary size diminished and T2-weighted signal tended to normalize.Conclusions: This comprehensive study of pituitary MRI characteristics in ectopic acromegaly underlines the utility of performing T2-weighted sequences in the MRI evaluation of patients with acromegaly as an additional tool that can help to establish the correct diagnosis.
Titel: |
Pituitary MRI Features in Acromegaly Resulting From Ectopic GHRH Secretion From a Neuroendocrine Tumor: Analysis of 30 Cases
|
---|---|
Autor/in / Beteiligte Person: | Potorac, Iulia ; Bonneville, Jean-François ; Daly, Adrian, F ; de Herder, Wouter ; Fainstein-Day, Patricia ; Chanson, Philippe ; Korbonits, Marta ; Cordido, Fernando ; Baranski Lamback, Elisa ; Abid, Mohamed ; Raverot, Véronique ; Raverot, Gerald ; Anda Apiñániz, Emma ; Caron, Philippe ; Du Boullay, Helene ; Bidlingmaier, Martin ; Bolanowski, Marek ; Laloi-Michelin, Marie ; Borson-Chazot, Francoise ; Chabre, Olivier ; Christin-Maitre, Sophie ; Briet, Claire ; Diaz-Soto, Gonzalo ; Bonneville, Fabrice ; Castinetti, Frederic ; Gadelha, Mônica, R ; Oliveira Santana, Nathalie ; Stelmachowska-Banaś, Maria ; Gudbjartsson, Tomas ; Villar-Taibo, Roció ; Zornitzki, Taiba ; Tshibanda, Luaba ; Petrossians, Patrick ; Beckers, Albert ; Université de Liège ; Centre Hospitalier Universitaire de Liège (CHU-Liège) ; Erasmus University Medical Center Rotterdam (Erasmus MC) ; Hospital Italiano - BUENOS AIRES (Hop It - BUENOS AIRES) ; AP-HP. Université Paris Saclay ; AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre) ; Physiologie et physiopathologie endocriniennes (PHYSENDO) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay ; Queen Mary University of London (QMUL) ; A Coruña University Hospital La Corogne, Espagne ; Universidade Federal do Rio de Janeiro Brasil = Federal University of Rio de Janeiro Brazil = Université fédérale de Rio de Janeiro Brésil (UFRJ) ; Hedi Chaker Hospital Sfax ; Groupement Hospitalier Lyon-Est (GHE) ; Hospices Civils de Lyon (HCL) ; Navarra Hospital Complex - Complejo Hospitalario de Navarra Pamplona, Spain (CHN) ; Centre Hospitalier Universitaire de Toulouse (CHU Toulouse) ; Centre Hospitalier Métropole Savoie Chambéry ; Medizinische Klinik und Poliklinik, IV ; Ludwig Maximilian University Munich = Ludwig Maximilians Universität München (LMU) ; Ludwig-Maximilians University Munich (LMU) ; Wrocław Medical University ; Hôpital Lariboisière-Fernand-Widal, APHP ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) ; Université Claude Bernard Lyon 1 (UCBL) ; Université de Lyon ; Centre Hospitalier Universitaire CHU Grenoble (CHUGA) ; CHU Saint-Antoine AP-HP ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU) ; Sorbonne Université - Faculté de Médecine (SU FM) ; Sorbonne Université (SU) ; Centre Hospitalier Universitaire d'Angers (CHU Angers) ; PRES Université Nantes Angers Le Mans (UNAM) ; Hospital Clinico Universitario de Valladolid Castilla y León, Spain (HCUV) ; Service Neuroradiologie Diagnostique et Thérapeutique CHU Toulouse ; Pôle imagerie médicale CHU Toulouse ; Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse) ; Aix Marseille Université (AMU) ; Universidade de São Paulo = University of São Paulo (USP) ; Centre of Postgraduate Medical Education Warsaw, Poland (CPME) ; Landspitali National University Hospital of Iceland ; Complejo Hospitalario Universitario de Santiago de Compostela Saint-Jacques-de-Compostelle, Espagne (CHUS) ; The Hebrew University Hadassah Medical School ; Fonds d’Investissment pour la Recherche (FIRS) of the Centre Hospitalier Universitaire de Liege (Grant Number 2018-2020) |
Link: | |
Zeitschrift: | ISSN: 0021-972X, 2023 |
Veröffentlichung: | HAL CCSD ; Endocrine Society, 2023 |
Medientyp: | academicJournal |
DOI: | 10.1210/clinem/dgac274 |
Schlagwort: |
|
Sonstiges: |
|