Ultrasonic analysis of plaque characteristics and intimal-medial thickness in radiation-induced atherosclerotic carotid arteries
In: European Journal of Vascular and Endovascular Surgery; European Journal Of Vascular And Endovascular Surgery, 2002, v. 24 n. 6, p. 499-504; 504; 81783; WOS:000179554600005; eid_2-s2.0-0036885033; 499; 24
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Zugriff:
Objectives: to investigate the effect of external irradiation on the morphology of atherosclerotic plaques and the intimal-medial thickness of the carotid artery. Methods: a group of 46 patients (16 symptomatic) who had received external irradiation to the head and neck area more than five years previously and developed carotid stenosis exceeding 50%, were evaluated by duplex ultrasound. The carotid artery lumen, intimal-medial complex, and the plaque echogenicity was determined using computer digital image processing methods, forty-six age and sex matched patients with similar degrees of non-radiation associated carotid stenosis were used as controls. Results: irradiated stenotic carotid arteries had a greater intimal-medial thickness (0.96 mm vs 0.80 mm, p = 0.008) and a narrower lumen (5.5 mm vs 6.6 mm, p < 0.002) than the controls. The carotid plaque characteristics (gray-scale median (GSM) and heterogeneity) of the irradiated and control groups did not differ significantly. Symptomatic patients who had received external radiotherapy to the head and neck have a more echolucent plaque (mean GSM of 98) than their asymptomatic counterparts (mean GSM 114, p = 0.03). Intimal-medial thickness and carotid lumen was not related to the occurrence of symptoms. Conclusions: external irradiation to the head and neck area leads to significantly increased thickness of the carotid wall and a corresponding narrowing of the lumen. There seems to be no difference in the plaque characteristics between irradiation-induced and spontaneous carotid atherosclerosis. © 2002 Elsevier Science Ltd. All rights reserved. ; link_to_subscribed_fulltext
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Ultrasonic analysis of plaque characteristics and intimal-medial thickness in radiation-induced atherosclerotic carotid arteries
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Autor/in / Beteiligte Person: | Wu, LLH ; Cheng, SWK ; Ting, ACW |
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Quelle: | European Journal of Vascular and Endovascular Surgery; European Journal Of Vascular And Endovascular Surgery, 2002, v. 24 n. 6, p. 499-504; 504; 81783; WOS:000179554600005; eid_2-s2.0-0036885033; 499; 24 |
Veröffentlichung: | //www.elsevier.com/locate/ejvs ; United Kingdom, 2002 |
Medientyp: | academicJournal |
ISBN: | 978-0-00-179554-9 (print) ; 0-00-179554-6 (print) |
ISSN: | 1078-5884 (print) |
DOI: | 10.1053/ejvs.2002.1752 |
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