Endothelial Progenitor Cells May Be Related to Major Amputation after Angioplasty in Patients with Critical Limb Ischemia
In: Cells, Vol 12, Iss 584, p 584 (2023, Jg. 12 (2023), Heft 584, p 584
Online
academicJournal
Zugriff:
Background: Critical limb ischemia represents an advanced stage of peripheral arterial disease. Angioplasty improves blood flow to the limb; however, some patients progress irreversibly to lower limb amputation. Few studies have explored the predictive potential of biomarkers during postangioplasty outcomes. Aim: To evaluate the behavior of endothelial progenitor cells in patients with critical limb ischemia, in relation to their postangioplasty outcome. Methods: Twenty patients with critical limb ischemia, candidates for angioplasty, were enrolled. Flow-mediated dilation, as well as endothelial progenitor cells (subpopulations CD45+/CD34+/CD133+/CD184+ and CD45+/CD/34+/KDR[VEGFR-2]+ estimated by flow cytometry) from blood flow close to vascular damage, were evaluated before and after angioplasty. Association with lower limb amputation during a 30-day follow-up was analyzed. Results: Endothelial progenitor cells were related with flow-mediated dilation. A higher number of baseline EPCs CD45 + CD34 + KDR + , as well as an impaired reactivity of endothelial progenitor cells CD45 + CD34 + CD133 + CD184 + after angioplasty, were observed in cases further undergoing major limb amputation, with a significant discrimination ability and risk (0.75, specificity 0.83 and RR 4.5 p < 0.05). Conclusions: Endothelial progenitor cells were related with endothelial dysfunction, whereas a higher baseline number of the subpopulation CD45 + CD34 + KDR + , as well as an impaired reactivity of subpopulation CD45 + CD34 + CD133 + CD184 + after angioplasty, showed a predictive ability for major limb amputation in patients with critical limb ischemia.
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Endothelial Progenitor Cells May Be Related to Major Amputation after Angioplasty in Patients with Critical Limb Ischemia
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Autor/in / Beteiligte Person: | Santillán-Cortez, Daniel ; Vera-Gómez, Eduardo ; Hernández-Patricio, Alejandro ; Atzín Suá Ruíz-Hernández ; Juan Ariel Gutiérrez-Buendía ; Karen De la Vega-Moreno ; Yasser Alberto Rizo-García ; Oscar Antonio Loman-Zuñiga ; Escotto-Sánchez, Ignacio ; Juan Miguel Rodríguez-Trejo ; Mario Antonio Téllez-González ; Christian Gabriel Toledo-Lozano ; Ortega-Rosas, Tania ; García, Silvia ; Mondragón-Terán, Paul ; Juan Antonio Suárez-Cuenca |
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Zeitschrift: | Cells, Vol 12, Iss 584, p 584 (2023, Jg. 12 (2023), Heft 584, p 584 |
Veröffentlichung: | MDPI AG, 2023 |
Medientyp: | academicJournal |
ISSN: | 2073-4409 (print) |
DOI: | 10.3390/cells12040584 |
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