Characterizing the hippocampal dentate gyrus involvement in temporal lobe epilepsy
In: Electronic Thesis and Dissertation Repository, 2024
Online
academicJournal
Zugriff:
The dentate gyrus (DG) plays a critical role in hippocampal circuitry, providing a “gate-like†function to the downstream Cornu Ammonis (CA) sectors. Despite this critical role, DG pathologies are not heavily considered in the diagnosis of mesial temporal lobe epilepsy (mTLE). To elucidate the role of the DG in mTLE, here we analyze hippocampal sclerosis (HS), no-HS, non-TLE epilepsy control, and non-epilepsy control cohorts using morphometry and gene expression profiling techniques. Our data show distinct DG morphometry and RNA expression profiles between HS and no-HS. Interestingly, regardless of pathological diagnosis, the DG morphometry correlates with patient’s post-operative outcome. Our data indicates differential expression of pathways including neurogenesis, complement system, and matrix remodeling between HS and no-HS DG. This study reveals possible prognostic value in DG morphometry, as well as supports the notion that HS and no-HS TLE may be distinct disease entities with differing contributing mechanisms.
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Characterizing the hippocampal dentate gyrus involvement in temporal lobe epilepsy
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Autor/in / Beteiligte Person: | Twible, Carolyn |
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Zeitschrift: | Electronic Thesis and Dissertation Repository, 2024 |
Veröffentlichung: | Scholarship@Western, 2024 |
Medientyp: | academicJournal |
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