Einzeltreffer — DigiBib

The aim of this study was to evaluate effects of IL-17F gene polymorphisms, rs2397084 (substitution of glutamic acid (GAG) for glycine (GGG) at position 126; Glu126Gly) and rs763780 (substitution of histidine (CAT) for arginine (CGT) at position 161; His161Arg) on the cystic fibrosis (CF) patients mortality rate. The study involved 82 patients who were regularly examined (every 3-6 months) and received antibiotic therapy. The frequency of IL-17F (rs2397084) A and G alleles was 90.2% and 9.8%, respectively. The frequency of IL-17F (rs763780) A and G alleles was 92.1% and 7.9%, respectively. The patients were divided into two groups. Group 1 included individuals with common AA-AA genotype (n=55). Group 2 included carriers of one or more minor G alleles (n=27). The patients of two groups did not differ in age, sex, or number of F508del mutation carriers. At the same time, there were 14 dead patients in group 1, whereas all patients from group 2 were alive. Thus, survival in groups 1 and 2 was 74.5% and 100%, respectively (p=0.0035, Fisher’s exact test). Analysis of the Kaplan-Meier curves showed that the overall survival of patients in the group 1 was significantly lower than the corresponding parameter in the group 2 (p=0.0026, Log-Rank Test). Repeated microbiological studies of sputum samples revealed a significant predominance of patients with chronic colonization of the Burkholderia cepacia complex (Bcc) in this group: 22 vs 1 patient in group 2 (χ2 = 11.82, p = 0.0006; OR 17.33 [95% CI 2.19-137.21]). Thus, increased mortality rate in CF patients with common AA-AA genotype is associated with a high incidence of chronic Bcc infection. Further investigations with increased number of participants are needed to estimate more accurately the true risks of Bcc infection and poor outcomes in CF patients with different IL-17F gene polymorphisms. ; Цель работы состояла в исследовании влияния аллельных полиморфизмов гена IL-17F rs2397084 (Glu126Gly) и rs763780 (His161Arg) на выживаемость пациентов с муковисцидозом. В ...

Titel:	IL-17F gene polymorphisms in cystic fibrosis patients: influence on mortality rate ; Влияние однонуклеотидных полиморфизмов гена IL-17F на выживаемость пациентов с муковисцидозом
Autor/in / Beteiligte Person:	Pukhalskaya, D. A. ; Shmarin, V. V. ; Semykin, S. U. ; Krasovsky, S. A. ; Bukina, T. M. ; Shmarina, G. V. ; Пухальская, Д. А. ; Шмарин, В. В. ; Семыкин, С. Ю. ; Красовский, С. А. ; Букина, Т. М. ; Шмарина, Г. В.
Link:	https://www.medgen-journal.ru/jour/article/view/2160/1627 https://www.medgen-journal.ru/jour/article/view/2160 https://doi.org/10.25557/2073-7998.2022.10.33-37 https://doi.org/10.1016/j.cyto.2008.12.024 https://doi.org/10.1038/s41590-018-0134-y https://doi.org/10.1164/rccm.201206-1150OC https://doi.org/10.1186/1465-9921-11-177 https://doi.org/10.1093/femspd/ftaa050 https://doi.org/10.1155/2014/602846 https://doi.org/10.1080/08916934.2016.1196678 https://doi.org/10.1016/j.clim.2020.108374 https://doi.org/10.1016/j.clae.2019.06.007
Zeitschrift:	Medical Genetics; Том 21, № 10 (2022); 33-37 ; Медицинская генетика; Том 21, 2022
Veröffentlichung:	Publishing House «Genius Media» LLC, 2022
Medientyp:	academicJournal
DOI:	10.25557/2073-7998.2022.10.33-37
Schlagwort:	цитокины IL-17F gene polymorphisms Burkholderia cepacia complex interleukin-17 cytokines полиморфизмы гена IL-17F интерлейкин-17
Sonstiges:	Nachgewiesen in: BASE Sprachen: Russian Collection: Medical Genetics (E-Journal) / Медицинская генетика Document Type: article in journal/newspaper File Description: application/pdf Language: Russian Relation: https://www.medgen-journal.ru/jour/article/view/2160/1627; Chang S.H., Dong C. IL-17F: regulation, signaling and function in inflammation. Cytokine. 2009 Apr;46(1):7-11. doi:10.1016/j.cyto.2008.12.024.; Tang C., Kakuta S., Shimizu K., et al. Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing Treg cells through modification of the intestinal microbiota. Nat Immunol. 2018 Jul;19(7):755-765. doi:10.1038/s41590-018-0134-y.; Tiringer K., Treis A., Fucik P., et al. A Th17- and Th2-skewed cytokine profile in cystic fibrosis lungs represents a potential risk factor for Pseudomonas aeruginosa infection. Am J Respir Crit Care Med. 2013 Mar 15;187(6):621-9. doi:10.1164/rccm.201206-1150OC.; Decraene A., Willems-Widyastuti A., Kasran A., et al. Elevated expression of both mRNA and protein levels of IL-17A in sputum of stable Cystic Fibrosis patients. Respir Res. 2010 Dec 10;11(1):177. doi:10.1186/1465-9921-11-177.; Oshalim M., Johansson E., Rabe H., et al. Th17 associated cytokines in sputum samples from patients with cystic fibrosis. Pathog Dis. 2020 Sep 26;78(6):ftaa050. doi:10.1093/femspd/ftaa050.; Ota K., Kawaguchi M., Matsukura S., et al. Potential involvement of IL-17F in asthma. J Immunol Res. 2014;2014:602846. doi:10.1155/2014/602846.; Paradowska-Gorycka A., Sowinska A., Stypinska B., et al. Impact of the IL-17F, IL-23 and IL-23R on susceptibility and phenotype of systemic lupus erythematosus. Autoimmunity. 2016 Sep;49(6):373-382. doi:10.1080/08916934.2016.1196678.; Shao M., Xu S., Yang H., et al. Association between IL-17A and IL-17F gene polymorphism and susceptibility in inflammatory arthritis: A meta-analysis. Clin Immunol. 2020 Apr;213:108374. doi:10.1016/j.clim.2020.108374.; Carnt N.A., Cipriani V., Stapleton F.J., et al. Association study of single nucleotide polymorphisms in IL-10 and IL-17 genes with the severity of microbial keratitis. Cont Lens Anterior Eye. 2019 Dec;42(6):658-661. doi:10.1016/j.clae.2019.06.007.; Eskandari-Nasab E., Moghadampour M., Tahmasebi A., Asadi-Saghandi A.Interleukin-17 A and F gene polymorphisms affect the risk of tuberculosis: An updated meta-analysis. Indian J Tuberc. 2018 Jul;65(3):200-207. doi:10.1016/j.ijtb.2017.08.027.; Чернуха М.Ю., Аветисян Л.Р., Шагинян И.А. и др. Алгоритм микробиологической диагностики хронической инфекции лёгких у больных муковисцидозом. Клиническая микробиология и антимикробная химиотерапия. 2014; 16(4):312-324.; Pawlik A., Kotrych D., Malinowski D., et al. IL17A and IL17F gene polymorphisms in patients with rheumatoid arthritis. BMC Musculoskelet Disord. 2016 May 11;17:208. doi:10.1186/s12891-016-1064-1.; Mazurek-Mochol M., Kozak M., Malinowski D., et al. IL-17F Gene rs763780 and IL-17A rs2275913 Polymorphisms in Patients with Periodontitis.Int J Environ Res Public Health. 2021 Jan 26;18(3):1081. doi:10.3390/ijerph18031081.; Ramsay K.A., Butler C.A., Paynter S., et al. Factors influencing acquisition of Burkholderia cepacia complex organisms in patients with cystic fibrosis. J Clin Microbiol. 2013 Dec;51(12):3975-80. doi:10.1128/JCM.01360-13.; https://www.medgen-journal.ru/jour/article/view/2160 Rights: Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access). ; Авторы, публикующие статьи в данном журнале, соглашаются на следующее:Авторы сохраняют за собой автороские права и предоставляют журналу право первой публикации работы, которая по истечении 6 месяцев после публикации автоматически лицензируется на условиях Creative Commons Attribution License , которая позволяет другим распространять данную работу с обязательным сохранением ссылок на авторов оригинальной работы и оригинальную публикацию в этом журнале.Авторы имеют право размещать их работу в сети Интернет (например в институтском хранилище или персональном сайте) до и во время процесса рассмотрения ее данным журналом, так как это может привести к продуктивному обсуждению и большему количеству ссылок на данную работу (См. The Effect of Open Access).

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

IL-17F gene polymorphisms in cystic fibrosis patients: influence on mortality rate ; Влияние однонуклеотидных полиморфизмов гена IL-17F на выживаемость пациентов с муковисцидозом