Fe-MIL-88NH 2 Metal–Organic Framework Nanocubes Decorated with Pt Nanoparticles for the Detection of Salmonella
2021
academicJournal
Zugriff:
Early screening of Salmonella is of utmost importance to minimize the incidence of related foodborne diseases. Here, we reported an immunosensor to fast detect Salmonella using Fe-MIL-88NH 2 metal–organic framework (Fe-MOF) nanocubes to load platinum nanoparticles (PtNPs) for signal amplification and smartphone thermal imaging to monitor the temperature change. The Fe-MOF nanocubes decorated with PtNPs (Fe-MOF/PtNPs) were prepared as peroxidase mimics to catalyze hydrogen peroxide (H 2 O 2 ) to produce O 2 . The immune magnetic nanoparticles (MNPs), the target bacteria, and the immune Fe-MOF/PtNPs were first mixed by the three-dimensional (3D) chaotic micromixer and conjugated in the microfluidic chip to form MNP–bacteria–Fe-MOF/PtNPs sandwich complexes. After magnetic separation and washing, H 2 O 2 was injected and decomposed by Fe-MOF/PtNPs on the sandwich complexes to generate O 2 in a sealed chamber. The increase in the pressure pushed the preloaded water to react with calcium oxide powder, resulting in the generation of heat, which was measured using the smartphone-based thermal sensor to determine the bacteria. The microfluidic immunosensor could detect Salmonella as low as 93 CFU/mL within 1 h.
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Fe-MIL-88NH 2 Metal–Organic Framework Nanocubes Decorated with Pt Nanoparticles for the Detection of Salmonella
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Autor/in / Beteiligte Person: | Ruya Guo (10661871) ; Li Xue (583505) ; Gaozhe Cai (8250783) ; Wuzhen Qi (8250786) ; Yuanjie Liu (203485) ; Jianhan Lin (1844233) |
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Veröffentlichung: | 2021 |
Medientyp: | academicJournal |
DOI: | 10.1021/acsanm.1c00574.s001 |
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