Chemotherapy with radiotherapy influences time-to-development of radiation-induced sarcomas: a multicenter study.
In: British journal of cancer, 2017, 117 (3), 2018, S. 326
Online
academicJournal
Zugriff:
Background An increasing number and proportion of cancer patients with apparently localised disease are treated with chemotherapy and radiation therapy in contemporary oncology practice. In a pilot study of radiation-induced sarcoma (RIS) patients, we demonstrated that chemotherapy was associated with a reduced time to development of RIS. We now present a multi-centre collaborative study to validate this association.Methods This was a retrospective cohort study of RIS cases across five large international sarcoma centres between 1 January 2000 to 31 December 2014. The primary endpoint was time to development of RIS.Results We identified 419 patients with RIS. Chemotherapy for the first malignancy was associated with a shorter time to RIS development (HR 1.37; 95% CI: 1.08-1.72; P=0.009). In the multi-variable model, older age (HR 2.11; 95% CI 1.83-2.43; P<0.001) and chemotherapy for the first malignancy (HR 1.61; 95% CI 1.26-2.05; P<0·001) were independently associated with a shorter time to RIS. Anthracyclines and alkylating agents significantly contribute to the effect.Conclusions This study confirms an association between chemotherapy given for the first malignancy and a shorter time to development of RIS.
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Chemotherapy with radiotherapy influences time-to-development of radiation-induced sarcomas: a multicenter study.
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Autor/in / Beteiligte Person: | Zhang, AY ; Judson, I ; Benson, C ; Wunder, JS ; Ray-Coquard, I ; Grimer, RJ ; Quek, R ; Wong, E ; Miah, AB ; Ferguson, PC ; Dufresne, A ; Teh, JYH ; Stockler, M ; Tattersall, MHN ; Miah, Aisha ; Judson, Ian ; Marsden |
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Zeitschrift: | British journal of cancer, 2017, 117 (3), 2018, S. 326 |
Veröffentlichung: | 2018 |
Medientyp: | academicJournal |
ISSN: | 0007-0920 (print) ; 1532-1827 (print) |
DOI: | 10.1038/bjc.2017.198 |
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