Adverse drug reactions after intravenous rituximab infusion are more common in hematologic malignancies than in autoimmune disorders and can be predicted by the combination of few clinical and laboratory parameters: results from a retrospective, multicenter study of 374 patients.
In: LEUKEMIA & LYMPHOMA, 2017, Heft 11, S. 2633-2641
Online
academicJournal
Zugriff:
Rituximab is an effective treatment for CD20þB-cell malignancies and autoimmune disorders.However, adverse drug reactions (ADRs) may occur after rituximab infusion, causing, in rarecases, its discontinuation. In this multicenter, retrospective study, among 374 patients treatedwith rituximab i.v., 23.5% experienced ADRs. Mean follow-up was 20.6 months (range 8–135).Overall, ADRs were significantly more frequent in non-Hodgkin lymphomas (NHL) and chroniclymphocytic leukemias (25–35.9%), than in autoimmune diseases (9.4–17.5%) (p<.0001). Grade3–4 toxicity was observed in eight patients (2.1%), and in four of them (1% of all patients) defini-tive drug discontinuation was necessary. Interestingly, three groups of patients with different riskof developing ADR were identified, according to a predictive heat-map developed combiningfour parameters (splenomegaly, history of allergy, hemoglobin levels and gender) selected bymultivariate analysis. This model may be useful in identifying patients at higher risk of ADRs,needing appropriate preventing therapies
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Adverse drug reactions after intravenous rituximab infusion are more common in hematologic malignancies than in autoimmune disorders and can be predicted by the combination of few clinical and laboratory parameters: results from a retrospective, multicenter study of 374 patients.
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Autor/in / Beteiligte Person: | D'Arena, G ; Simeon, V ; Laurenti, L ; Cimminiello, M ; Innocenti, I ; Gilio, M ; Padula, A ; Vigliotti, Ml ; De Lorenzo, S ; Loseto, G ; PASSARELLI, ANNA ; Di Minno, Mn ; TUCCI, MARCO GAETANO ; De Feo, V ; D'Auria, F ; SILVESTRIS, Francesco ; Di Minno, G ; Passarelli, Anna ; Tucci, MARCO GAETANO ; Silvestris, Francesco |
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Zeitschrift: | LEUKEMIA & LYMPHOMA, 2017, Heft 11, S. 2633-2641 |
Veröffentlichung: | 2017 |
Medientyp: | academicJournal |
DOI: | 10.1080/10428194.2017.1306648 |
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