Comparison of biophysical models with experimental data for three cell lines in response to irradiation with monoenergetic ions
In: ISSN: 2405-6316 ; Physics and Imaging in Radiation Oncology ; https://hal.science/hal-02543068 ; Physics and Imaging in Radiation Oncology, 2019, 12, pp.17-21. ⟨10.1016/j.phro.2019.10.004⟩, 2019
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International audience ; HighlightsThe accuracy of biophysical modeling is crucial for particle therapy.Comparison of LEM(I-IV), MKM and NanOx models with data for 3 cell lines. χ2 scoring for α(LET) curves. NanOx yields the highest score more often than the other models.AbstractThe relative biological effectiveness (RBE) in particle therapy is currently estimated using biophysical models. We compared experimental measurements to the α curves as function of linear energy transfer computed by the Local Effect Model (LEM I-IV), the Microdosimetric Kinetic Model (MKM) and the NanOx model for HSG, V79 and CHO-K1 cells in response to monoenergetic irradiations. Although the LEM IV and the MKM predictions accurately reproduced the trend observed in the data, NanOx yielded a better agreement than the other models for more irradiation configurations. Itsestimator was indeed the lowest for three over seven considered cases.
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Comparison of biophysical models with experimental data for three cell lines in response to irradiation with monoenergetic ions
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| Autor/in / Beteiligte Person: | Monini, Caterina ; Alphonse, Gersende ; Rodriguez-Lafrasse, Claire ; Testa, Etienne ; Beuve, Michael ; Institut de Physique des 2 Infinis de Lyon (IP2I Lyon) ; Université Claude Bernard Lyon 1 (UCBL) ; Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS) ; Laboratoire de Radiobiologie Cellulaire et Moléculaire ; Faculté de Médecine Lyon-Sud ; Service de biochimie ; hospices civils de Lyon |
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| Zeitschrift: | ISSN: 2405-6316 ; Physics and Imaging in Radiation Oncology ; https://hal.science/hal-02543068 ; Physics and Imaging in Radiation Oncology, 2019, 12, pp.17-21. ⟨10.1016/j.phro.2019.10.004⟩, 2019 |
| Veröffentlichung: | HAL CCSD ; ESTRO, the European SocieTy for Radiotherapy & Oncology, 2019 |
| Medientyp: | academicJournal |
| DOI: | 10.1016/j.phro.2019.10.004 |
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