PS1085 ORAL CHOP LIKE CHEMOTHERAPY IN ELDERLY PATIENTS WITH HIGH‐GRADE NON HODGKIN B CELL LYMPHOMA
In: HemaSphere, Jg. 3 (2019), Heft S1, S. 492
academicJournal
Zugriff:
Background: The Doxorubicin based R‐CHOP regimen remains the standard of care for the upfront treatment of DLBCL. The advent of oral idarubicin permitted to develop an all‐oral ambulatory oro‐CIEP regimen. Aims: We hypothesized this regimen would improve the treatment of elderly DLBCL. Methods: We have performed a phase 1/2 study to determine the MTD[CA1] of idarubicin in the oro‐CIEP regimen. Idarubicin was orally administrated on day 1 with starting dose at 20 mg/m 2 and escalated per 10 mg/m 2 increment. Results: Twenty‐six newly diagnosed patients were enrolled, median age of 71 years (range, 62–80). All first 3 patients developed a DLT at level 3 (40 mg/m2), and 14 patients were then enrolled at RP2D 30 mg/m 2 in the phase 2. The most significant hematological toxicities were thrombocytopenia grade 3 or 4 (3.3%) and neutropenia grade 3 or 4 (26%); and extra‐hematological toxicities were infectious disease (5% grade 3 or 4). Second primary malignancies were reported in three patients. No toxic related death was observed. ORR and CR rates were 85% and 77%, respectively. The 5‐year overall survival and event free survival were 65% (95%CI 41;81) and 65% (95%CI 42;81), respectively. Summary/Conclusion: This analysis shows that oral idarubicin at the MTD of 30 mg/m 2 is safe and active in elderly DLBCL. The results we have observed, particularly overall survival seemed to be superimposable to previous publications with the regular CHOP‐like regimens for this population. Further improvements in the protocol will be introduced with the subcutaneous anti‐CD20 immunotherapy approach. This data needs to be confirmed in the context of a larger study.
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PS1085 ORAL CHOP LIKE CHEMOTHERAPY IN ELDERLY PATIENTS WITH HIGH‐GRADE NON HODGKIN B CELL LYMPHOMA
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Autor/in / Beteiligte Person: | Guidez, S. ; Tomowiak, C. ; Princet, I. ; Motard, C. ; Corby, A. ; Machet, A. ; Debiais, C. ; Guilhot, J. ; Delwail, V. |
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Zeitschrift: | HemaSphere, Jg. 3 (2019), Heft S1, S. 492 |
Veröffentlichung: | Wiley, 2019 |
Medientyp: | academicJournal |
ISSN: | 2572-9241 |
DOI: | 10.1097/01.hs9.0000562632.16851.d3 |
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