Respective role of non-pharmaceutical interventions on bronchiolitis outbreaks, an interrupted time series analysis based on a multinational surveillance system
In: ISSN: 0903-1936, 2022
Online
academicJournal
Zugriff:
International audience ; Background Bronchiolitis is a major source of morbimortality among young children worldwide. Non-pharmaceutical interventions (NPIs) implemented to reduce the spread of SARS-CoV-2 may have had an important impact on bronchiolitis outbreaks, as well as major societal consequences. Discriminating between their respective impacts would help define optimal public health strategies against bronchiolitis. We aimed to assess the respective impact of each NPI on bronchiolitis outbreaks in 14 European countries. Methods We conducted a quasi-experimental interrupted time-series analysis based on a multicentre international study. All children diagnosed with bronchiolitis presenting to the paediatric emergency department of one of the 27 centres from January 2018 to March 2021 were included. We assessed the association between each NPI and change in the bronchiolitis trend over time by seasonally adjusted multivariable quasi-Poisson regression modelling. Results In total, 42 916 children were included. We observed an overall cumulative 78% reduction (95%CI [−100;−54], p<0.0001) in bronchiolitis cases following NPI implementation. The decrease varied between countries from −97% (95%CI [−100;−47], p=0.0005) to −36% (95%CI [−79;+07], p=0.105). Full lockdown (IRR 0.21, 95%CI [0.14;0.30], p<0.001), secondary-school closure (IRR 0.33, 95%CI [0.20;0.52], p<0.0001), wearing a mask indoors (IRR 0.49, 95%CI [0.25;0.94], p=0.034), and teleworking (IRR 0.55, 95%CI [0.31;0.97], p=0.038) were independently associated with reducing bronchiolitis. Conclusion Several NPIs were associated with a reduction of bronchiolitis outbreaks, including full lockdown, school closure, teleworking and facial masking. Some of these public health interventions may be considered to further reduce the global burden of bronchiolitis.
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Respective role of non-pharmaceutical interventions on bronchiolitis outbreaks, an interrupted time series analysis based on a multinational surveillance system
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Autor/in / Beteiligte Person: | Lenglart, Lea ; Ouldali, Naim ; Honeyford, Kate ; Bognar, Zsolt ; Bressan, Silvia ; Buonsenso, Danilo ; da Dalt, Liviana ; De, Tisham ; Farrugia, Ruth ; Maconochie, Ian ; Moll, Henriette ; Oostenbrink, Rianne ; Parri, Niccolo ; Roland, Damian ; Rose, Katy ; Akyüz Özkan, Esra ; Angoulvant, François ; Aupiais, Camille ; Barber, Clarissa ; Barrett, Michael ; Basmaci, Romain ; Castanhinha, Susana ; Chiaretti, Antonio ; Durnin, Sheena ; Fitzpatrick, Patrick ; Fodor, Laszlo ; Gomez, Borja ; Greber-Platzer, Susanne ; Guedj, Romain ; Hey, Florian ; Jankauskaite, Lina ; Kohlfuerst, Daniela ; Mascarenhas, Ines ; Musolino, Anna Maria ; Pučuka, Zanda ; Reis, Sofia ; Rybak, Alexis ; Salamon, Petra ; Schaffert, Matthias ; Shahar-Nissan, Keren ; Supino, Maria Chiara ; Teksam, Ozlem ; Turan, Caner ; Velasco, Roberto ; Nijman, Ruud ; Titomanlio, Luigi ; Anacleto, Vanda ; Aydin, Orkun ; Bellelli, Elena ; Berant, Ron ; de Groc, Thibault ; Geitoeira, Sara ; Hoffmann, Florian ; Leeb, Franziska ; Leonard, Fiona ; Lyttle, Mark ; Mano, Lia ; Masillonis, Vytenis ; Morello, Rosa ; Saraiva, Francisa ; Simon, Gabor ; Costa, Ines Silva ; Marques, Joao Sous ; Thüminger, Jonas ; Vasilico, Corinne ; Vittucci, Anna Chiara ; Zurl, Christoph ; Hôpital Robert Debré ; Hôpital Robert Debré-Hôpital universitaire Robert Debré Reims ; CHU Sainte Justine Montréal ; Epidémiologie Clinique et Evaluation Economique Appliquées aux Populations Vulnérables (ECEVE (U1123 / UMR_S_1123)) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-AP-HP Hôpital universitaire Robert-Debré Paris ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Cité (UPCité) ; Association Clinique et Thérapeutique Infantile du Val de Marne (ACTIV) ; The institute of cancer research London ; Pál Heim Children's Hospital = Heim Pál Gyermekkórház Budapest ; Azienda Ospedale Università di Padova = Hospital-University of Padua (AOUP) ; Fondazione Policlinico Universitario Agostino Gemelli, IRCCS ; Imperial College London ; Mater Dei Hospital Malta ; St Mary's Hospital London ; Hammersmith Hospital NHS Imperial College Healthcare ; Erasmus University Medical Center Rotterdam (Erasmus MC) ; Azienda Ospedaliero Universitaria A. Meyer Firenze, Italy ; University of Leicester ; University Hospitals Leicester ; Ondokuz Mayis University (OMU) ; Université Paris Cité (UPCité) ; AP-HP Hôpital universitaire Robert-Debré Paris ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) ; Hôpital Jean Verdier AP-HP ; North Bristol NHS Trust Bristol, UK ; Children's Health Ireland Crumlin, Dublin, Ireland (CHI) ; University College Dublin Dublin (UCD) ; Hôpital Louis Mourier - AP-HP Colombes ; Centro Hospitalar de Lisboa Central E.P.E ; CHI at Tallaght Children's Outpatient and Emergency Care Unit Tallaght, Ireland (COECU) ; CHI at Temple Street Temple Street, Ireland (TS) ; Fejér County Szent György University Teaching Hospital Szekesfehervar, Hungary (FCSGUTH) ; Hospital Universitario Cruces = Cruces University Hospital ; Medizinische Universität Wien = Medical University of Vienna ; Obstetrical, Perinatal and Pediatric Epidemiology ; Centre for Research in Epidemiology and Statistics ; Conservatoire National des Arts et Métiers CNAM (CNAM) ; HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers CNAM (CNAM) ; HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) ; Dr von Hauner Children's Hospital Munich, Germany ; Ludwig Maximilian University Munich = Ludwig Maximilians Universität München (LMU) ; Ludwig-Maximilians University Munich (LMU) ; Hospital of Lithuanian University of Health Sciences Kauno Klinikos Kaunas, Lithuania ; Medical University of Graz ; Hospital Prof Doutor Fernando Fonseca Amadora, Portugal ; IRCCS Ospedale Pediatrico Bambino Gesù = Bambino Gesù Children’s Hospital ; Children's Clinical University Hospital Riga, Latvia (CCUH) ; Centro Hospitalar Tondela-Viseu Viseu, Portugal (CHTV) ; Paracelsus Medizinische Privatuniversität = Paracelsus Medical University (PMU) ; Schneider Children’s Medical Center Petah Tikva, Israel (SCMC) ; Hacettepe University = Hacettepe Üniversitesi ; University, Mersin ; Rio Hortega University Hospital (Hospital Universitario Río Hortega) Valladolid, Spain (RHUH) ; Maladies neurodéveloppementales et neurovasculaires (NeuroDiderot (UMR_S_1141 / U1141)) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité) ; EPISODES Study Group. |
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Zeitschrift: | ISSN: 0903-1936, 2022 |
Veröffentlichung: | HAL CCSD ; European Respiratory Society, 2022 |
Medientyp: | academicJournal |
DOI: | 10.1183/13993003.01172-2022 |
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