Association of Thyroid Dysfunction With Cognitive Function: An Individual Participant Data Analysis
In: ISSN: 2168-6106, 2021
Online
academicJournal
Zugriff:
International audience ; Importance: In clinical guidelines, overt and subclinical thyroid dysfunction are mentioned as causal and treatable factors for cognitive decline. However, the scientific literature on these associations shows inconsistent findings. Objective: To assess cross-sectional and longitudinal associations of baseline thyroid dysfunction with cognitive function and dementia. Design, Setting, and Participants: This multicohort individual participant data analysis assessed 114267 person-years (median, 1.7-11.3 years) of follow-up for cognitive function and 525222 person-years (median, 3.8-15.3 years) for dementia between 1989 and 2017. Analyses on cognitive function included 21 cohorts comprising 38144 participants. Analyses on dementia included eight cohorts with a total of 2033 cases with dementia and 44573 controls. Data analysis was performed from December 2016 to January 2021. Exposures: Thyroid function was classified as overt hyperthyroidism, subclinical hyperthyroidism, euthyroidism, subclinical hypothyroidism, and overt hypothyroidism based on uniform thyrotropin cutoff values and study-specific free thyroxine values. Main Outcomes and Measures: The primary outcome was global cognitive function, mostly measured using the Mini-Mental State Examination. Executive function, memory, and dementia were secondary outcomes. Analyses were first performed at study level using multivariable linear regression and multivariable Cox regression, respectively. The studies were combined with restricted maximum likelihood meta-analysis. To overcome the use of different scales, results were transformed to standardized mean differences. For incident dementia, hazard ratios were calculated. Results: Among 74565 total participants, 66567 (89.3%) participants had normal thyroid function, 577 (0.8%) had overt hyperthyroidism, 2557 (3.4%) had subclinical hyperthyroidism, 4167 (5.6%) had subclinical hypothyroidism, and 697 (0.9%) had overt hypothyroidism. The study-specific median age at baseline varied from 57 to ...
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Association of Thyroid Dysfunction With Cognitive Function: An Individual Participant Data Analysis
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| Autor/in / Beteiligte Person: | VAN VLIET, Nicolien A. ; van Heemst, Diana ; Almeida, Osvaldo P. ; ASVOLD, Bjorn O. ; AUBERT, Carole E. ; Bae, Jong Bin ; BARNES, Linda E. ; BAUER, Douglas C. ; BLAUW, Gerard J. ; Brayne, Carol ; CAPPOLA, Anne R. ; CERESINI, Graziano ; COMIJS, Hannie C. ; DARTIGUES, Jean Francois ; DEGRYSE, Jean-Marie ; DULLAART, Robin P. F. ; VAN EERSEL, Marlise E. A. ; DEN ELZEN, Wendy P. J. ; Ferrucci, Luigi ; FINK, Howard A. ; Flicker, Leon ; Grabe, Hans J. ; Han, Ji Won ; Helmer, Catherine ; Huisman, Martijn ; Ikram, M. Arfan ; IMAIZUMI, Misa ; DE JONGH, Renate T. ; Jukema, J. Wouter ; Kim, Ki Woong ; KULLER, Lewis H. ; Lopez, Oscar L. ; MOOIJAART, Simon P. ; MOON, Jae Hoon ; MOUTZOURI, Elisavet ; Nauck, Matthias ; PARLE, Jim ; PEETERS, Robin P. ; SAMUELS, Mary H. ; SCHMIDT, Carsten O. ; SCHMINKE, Ulf ; Slagboom, P. Eline ; Stordal, Eystein ; VAES, Bert ; VOLZKE, Henry ; WESTENDORP, Rudi G. J. ; YAMADA, Michiko ; Yeap, Bu B. ; Rodondi, Nicolas ; Gussekloo, Jacobijn ; Trompet, Stella ; Leiden University Medical Center (LUMC) ; The University of Western Australia (UWA) ; Norwegian University of Science and Technology Trondheim (NTNU) ; Norwegian University of Science and Technology (NTNU) ; Department of Psychiatry St. Olav's hospital, Trondheim ; St. Olav's Hospital ; Bern University Hospital Berne (Inselspital) ; University of Bern ; University of Michigan Ann Arbor ; University of Michigan System ; Seoul National University Bundang Hospital (SNUBH) ; University of Cambridge UK (CAM) ; University of California San Francisco (UCSF) ; University of California ; University of Pennsylvania Philadelphia ; University Hospital of Parma Parme, Italie ; Vrije Universiteit Amsterdam Amsterdam (VU) ; Bordeaux population health (BPH) ; Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM) ; Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven) ; University of Groningen Groningen ; Amsterdam, UMC ; Hospital, Harbor ; National Institute on Aging, Baltimore ; VA Healthcare System ; University of Minnesota MN, USA ; University of Medicine Greifswald ; German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) ; Vrije universiteit = Free university of Amsterdam Amsterdam (VU) ; Erasmus University Medical Center Rotterdam (Erasmus MC) ; Radiation Effects Research Foundation ; ICIN - Netherlands Heart Institute ; Seoul National University College of Natural Sciences ; Seoul National University Seoul (SNU) ; University of Pittsburgh (PITT) ; Pennsylvania Commonwealth System of Higher Education (PCSHE) ; University of Pittsburgh School of Medicine ; German Center for Cardiovascular Research (DZHK) ; Berlin Institute of Health (BIH) ; University of Birmingham Birmingham ; Oregon Health and Science University Portland (OHSU) ; Max planck Institute for Biology of Ageing Cologne ; University of Copenhagen = Københavns Universitet (KU) ; Radiation Effects Research Foundation (RERF) ; Fiona Stanley Hospital Murdoch |
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| Zeitschrift: | ISSN: 2168-6106, 2021 |
| Veröffentlichung: | HAL CCSD ; American Medical Association, 2021 |
| Medientyp: | academicJournal |
| DOI: | 10.1001/jamainternmed.2021.5078 |
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