Polyoxazolines based lipid nanocapsules for topical delivery of antioxidants
In: ISSN: 0378-5173 ; International Journal of Pharmaceutics ; https://hal.science/hal-03037735 ; International Journal of Pharmaceutics, 2020, 579, pp.119126. ⟨10.1016/j.ijpharm.2020.119126⟩, 2020
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Zugriff:
International audience ; Nano-sized lipid formulations offer a great potential for topical delivery of active compounds to treat and prevent human skin damages. Of particular importance is the high loading of hydrophobic molecules, the long-term stability and the auspicious penetration capacity especially reached when using lipid nanocapsules (LNC). Unfortunately, their formation currently relies on a phase inversion process that only operates when using a poly(ethylene glycol) (PEG) based surfactant belonging to the controversial PEG family that was subject of clinical awareness. The present study proposes an alternative to this overused polymer in formulations by designing LNC made of harmless amphiphilic polyoxazolines (POx). Implementing a short sonication step in the process allowed well-defined spherical nanoparticles of ~30 nm to be obtained. The structure of the so called LNC POx was composed of an oily core surrounded by a rigid shell of phospholipids and POx, which ensures a high stability over time, temperature, centrifugation and freezing. Encapsulation of the natural quercetin antioxidant led to a drug loading three times higher than for LNC constituted of PEG (LNC PEG). The antioxidant activity of loaded LNC POx was tested on mice fibroblasts and human keratinocytes after exposure to free radicals from peroxides and UVB irradiation, respectively. The radical scavenging capacity of quercetin loaded in the LNC POx was preserved and even slightly enhanced compared to LNC PEG, highlighting the POx value in nanoformulations.
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Polyoxazolines based lipid nanocapsules for topical delivery of antioxidants
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Autor/in / Beteiligte Person: | Simon, L. ; Lapinte, V. ; Lionnard, L. ; Marcotte, N. ; Morille, M. ; Aouacheria, Abdel ; Kissa, K. ; Devoisselle, J.M., M ; Begu, S. ; Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM) ; Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS) ; Institut des Sciences de l'Evolution de Montpellier (UMR ISEM) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE) ; Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement IRD : UR226-Centre National de la Recherche Scientifique (CNRS) ; Dynamique des interactions membranaires normales et pathologiques (DIMNP) ; Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS) |
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Zeitschrift: | ISSN: 0378-5173 ; International Journal of Pharmaceutics ; https://hal.science/hal-03037735 ; International Journal of Pharmaceutics, 2020, 579, pp.119126. ⟨10.1016/j.ijpharm.2020.119126⟩, 2020 |
Veröffentlichung: | HAL CCSD ; Elsevier, 2020 |
Medientyp: | academicJournal |
DOI: | 10.1016/j.ijpharm.2020.119126 |
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