Defining unknown steps in Coenzyme Q precursor biosynthesis
In: The FASEB Journal ; volume 33, issue S1 ; ISSN 0892-6638 1530-6860, 2019
academicJournal
Zugriff:
Coenzyme Q (CoQ) is a redox‐active lipid that is essential for cellular respiration and plays important roles in cellular metabolism. CoQ is produced endogenously by virtually all cells, yet multiple steps of its biosynthesis remain uncharacterized. It has been known for over fifty years that the conserved precursor for CoQ biosynthesis, 4‐hydroxybenzoic acid (4‐HB), is derived from tyrosine, but most of the metabolic steps involved in 4‐HB production have not been elucidated in eukaryotes. This pathway contains significant redundancy, and all but the first and last steps are uncharacterized. We are employing mass spectrometry, genetic screens, and classical biochemistry to discover novel intermediates and enzymes involved 4‐HB biosynthesis. Through characterization of critical enzymes and identification of pertinent intermediates, we hope to put together a comprehensive pathway detailing 4‐HB biosynthesis in eukaryotic organisms. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
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Defining unknown steps in Coenzyme Q precursor biosynthesis
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Autor/in / Beteiligte Person: | Johnson, Sheila ; Robinson, Kyle ; Pagliarini, Dave |
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Zeitschrift: | The FASEB Journal ; volume 33, issue S1 ; ISSN 0892-6638 1530-6860, 2019 |
Veröffentlichung: | Wiley, 2019 |
Medientyp: | academicJournal |
DOI: | 10.1096/fasebj.2019.33.1_supplement.461.8 |
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