Baseline predictors for visual acuity loss during observation in diabetic macular oedema with good baseline visual acuity
In: ISSN: 1395-3931 ; Acta Ophthalmologica Scandinavica -Supplement- ; https://hal.inrae.fr/hal-02964118 ; Acta Ophthalmologica Scandinavica -Supplement-, 2020, 98 (7), pp.E801-E806. ⟨10.1111/aos.14390⟩ ; https://onlinelibrary.wiley.com/doi/abs/10.1111/aos.14390, 2020
academicJournal
Zugriff:
International audience ; Purpose: To investigate clinical baseline characteristics and optical coherence tomography biomarkers predicting visual loss during observation in eyes with diabetic macular oedema (DMO) and good baseline visual acuity (VA). Methods: A sub-analysis of a 12-month, retrospective study, including patients with baseline VA ≤0.1 logMAR (≥20/25 Snellen) and centre-involving DMO. The primary outcome measure was the correlation between baseline characteristics and VA loss ≥10 letters during follow-up. Results: A total of 249 eyes were included in the initial study, of which 147 eyes were observed and 80 eyes received anti-vascular endothelial growth factor (VEGF) treatment at baseline. Visual acuity (VA) loss ≥10 letters occurred in 21.8% (observed cohort) and in 24.3% (treated cohort), respectively. Within observed eyes, presence of hyperreflective foci [HRF; odds ratio (OR): 3.18, p = 0.046], and disorganization of inner retina layers (DRIL; OR: 2.71, p = 0.026) were associated with a higher risk of VA loss ≥10 letters. In observed eyes with a combined presence of HRF, DRIL and ellipsoid zone (EZ) disruption, the risk of VA loss was further increased (OR: 3.86, p = 0.034). In eyes with combined presence of DRIL, HRF and EZ disruption, risk of VA loss was 46.7% (7/15 eyes) in the observed cohort, and 26.3% (5/19 eyes) in the treated cohort (p = 0.26). Conclusion: Patients with DMO and good baseline VA, managed by observation, are of increased risk for VA loss if DRIL, HRF and EZ disruption are present at baseline. Earlier treatment with anti-VEGF in these patients may potentially decrease the risk of VA loss at 12 months.
Titel: |
Baseline predictors for visual acuity loss during observation in diabetic macular oedema with good baseline visual acuity
|
---|---|
Autor/in / Beteiligte Person: | Busch, Catharina ; Okada, Mali ; Zur, Dinah ; Fraser‐bell, Samantha ; Rodríguez‐valdés, Patricio ; Cebeci, Zafer ; Lupidi, Marco ; Fung, Adrian ; Gabrielle, Pierre‐henry ; Giancipoli, Ermete ; Chaikitmongkol, Voraporn ; Laíns, Inês ; Santos, Ana Rita ; Kunavisarut, Paradee ; Sala‐puigdollers, Anna ; Chhablani, Jay ; Ozimek, Malgorzata ; Hilely, Assaf ; Degenhardt, Valentin ; Loewenstein, Anat ; Iglicki, Matias ; Rehak, Matus ; Department of Ophthalmology Leipzig ; University Hospital Leipzig ; Royal Victorian Eye and Ear Hospital ; Division of Ophthalmology ; Tel Aviv Sourasky Medical Center Te Aviv ; Sackler Faculty of Medicine ; Tel Aviv University (TAU) ; Discipline of Clinical Ophthalmology and Eye Health ; The University of Sydney ; Instituto de Oftalmología y Ciencias Visuales ; Escuela de Medicina ; Tecnológico de Monterrey (ITESM)-Tecnológico de Monterrey (ITESM) ; Department of Ophthalmology ; Istanbul Faculty of Medicine ; Istanbul University-Istanbul University ; Department of Biomedical and Surgical Sciences ; Section of Ophthalmology ; Università degli Studi di Perugia = University of Perugia (UNIPG)-Università degli Studi di Perugia = University of Perugia (UNIPG) ; Westmead Hospital Sydney ; Faculty of Medicine and Health Sciences ; Macquarie University Hospital ; Partenaires INRAE-Partenaires, INRAE ; Department, Ophthalmology ; Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon) ; Centre des Sciences du Goût et de l'Alimentation Dijon (CSGA) ; Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) ; Department of Surgical ; Microsurgical and Medical Sciences ; Clinic, Eye ; Università degli Studi di Sassari = University of Sassari Sassari (UNISS)-Università degli Studi di Sassari = University of Sassari Sassari (UNISS)-Eye Clinic ; Università degli Studi di Sassari = University of Sassari Sassari (UNISS)-Università degli Studi di Sassari = University of Sassari Sassari (UNISS) ; Department of Biomedical Sciences ; Università degli Studi di Sassari = University of Sassari Sassari (UNISS) ; Division, Retina ; Faculty of Medicine ; Chiang Mai University (CMU)-Chiang Mai University (CMU)-Faculty of Medicine ; Chiang Mai University (CMU)-Chiang Mai University (CMU) ; University of Coimbra Portugal (UC) ; Association for Innovation and Biomedical Research on Light and Image (AIBILI) ; Massachusetts Eye and Ear ; Harvard Medical School Boston (HMS) ; Department of Orthoptics ; Superior School of Health ; Polytechnic Institute of Porto-Polytechnic Institute of Porto ; Institut Clínic d'Oftalmologia (ICOF) ; Hospital Clínic de Barcelona ; UPMC Eye Center ; University of Pittsburgh (PITT) ; Pennsylvania Commonwealth System of Higher Education (PCSHE)-Pennsylvania Commonwealth System of Higher Education (PCSHE) ; L.V. Prasad Eye Institute ; Partenaires, INRAE ; Department of General Ophthalmology and Pediatric Ophthalmology Service ; Medical University of Lublin ; Heidelberg University Hospital Heidelberg ; Incumbent ; Sydney A. Fox chair in Ophthalmology ; Tel Aviv University (TAU)-Tel Aviv University (TAU) ; Private Retina Service ; Universitad de Buenos Aires = University of Buenos Aires Argentina |
Link: | |
Zeitschrift: | ISSN: 1395-3931 ; Acta Ophthalmologica Scandinavica -Supplement- ; https://hal.inrae.fr/hal-02964118 ; Acta Ophthalmologica Scandinavica -Supplement-, 2020, 98 (7), pp.E801-E806. ⟨10.1111/aos.14390⟩ ; https://onlinelibrary.wiley.com/doi/abs/10.1111/aos.14390, 2020 |
Veröffentlichung: | HAL CCSD, 2020 |
Medientyp: | academicJournal |
DOI: | 10.1111/aos.14390 |
Schlagwort: |
|
Sonstiges: |
|