Deep Sequencing of Immunoglobulin Genes Identifies a Very Low Percentage of Monoclonal B Cells in Primary Cutaneous Marginal Zone Lymphomas with CD30-Positive Hodgkin/Reed–Sternberg-like Cells
In: DIAGNOSTICS, 2022, Heft 2, S. 1-12
Online
academicJournal
Zugriff:
The spectrum of cutaneous CD30-positive lymphoproliferative disorders encompasses both inflammatory and neoplastic conditions. CD30+ Hodgkin and Reed–Sternberg-like cells have been occasionally reported in primary cutaneous marginal zone lymphoma, where they are thought to represent a side neoplastic component within a dominant background of lymphomatous small B cells. Herein, we describe the histological and molecular findings of three cases of primary cutaneous marginal zone lymphomas with CD30+ H/RS cells, in which next-generation sequencing analysis revealed the clonal population to consist in less than 5% of the cutaneous B-cell infiltrate, providing a thought-provoking focus on a possible main role for CD30+ cells in primary cutaneous marginal zone lymphoproliferations.
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Deep Sequencing of Immunoglobulin Genes Identifies a Very Low Percentage of Monoclonal B Cells in Primary Cutaneous Marginal Zone Lymphomas with CD30-Positive Hodgkin/Reed–Sternberg-like Cells
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Autor/in / Beteiligte Person: | Di Napoli A. ; Rogges, E. ; Noccioli, N. ; Gazzola, A. ; Lopez, G. ; Persechino, S. ; Mancini, R. ; Sabattini, E. ; Di Napoli, A. |
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Zeitschrift: | DIAGNOSTICS, 2022, Heft 2, S. 1-12 |
Veröffentlichung: | MDPI, 2022 |
Medientyp: | academicJournal |
DOI: | 10.3390/diagnostics12020290 |
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