The therapeutic effect of PAM-2 Cl on armin poisoned mice ; Terapijski učinak PAM-2-hlorida na miševima otrovanim arminom
In: Arhiv za higijenu rada i toksikologiju ; ISSN 0004-1254 (Print) ; ISSN 1848-6312 (Online) ; Volume 12 ; Issue 3-4, 1961
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Zugriff:
PAM-2 Cl (pyridine-2-aldoxime methyl chloride) was obtained by allowing the solution of PAM-2 (pyridine-2-aldoxime methyl iodide) to pass through the anion exchanger Duolit A-30 or by boiling a saturated PAM-2 solution with AgCI. The yield was 35-50%, m. p. 218-220° C (uncor.), solubility in water 1:1. The concentration of 1.10-4 PAM-2 Cl produces a 25% inhibition of the rabbit's plasma and erythrocyte ChE. The concentration of 1.10-4 PAM-2 Cl produces, in an hour, 80% reactivation of the same enzymes inhibited by armin (ethyl-p-nitrophenyl ethylphosphonate). The same results were obtained with PAM-2. The protective effect of P AM-2 Cl on the mice poisoned by armin is equal to that of PAM-2 regarding both the dose and the time of application. ; PAM-2 CI (piridin-2-aldoksim metilhiorid) dobiven je propuštanjem rastvora PAM-2 (piridin-2-aidoksim metiljodid) kroz anionski izmjenjivač Duolit A-30 ili kuhanjem zasićenog rastvora PAM-2 sa AgCI. Iskorištenje 35-50%, t. t. 218-20° C (nekor). Rastvorljivost u vodi 50%. Koncentracija od 1.10-3M PAM-2 CI dovodi do 25% inhibicije ChE plazme i eritrocita zeca, a koncentracija od 1.10-4M dovodi kroz Ih do 800/o reaktivacije ChE plazme i eritrocita zeca (kunića) inhibiranih arminom. Iste vrednosti dobivene su i sa PAM-2. Zaštitno dejstvo PAM-2 CI kod miševa otrovanih arminom jednako je dejstvu PAM-2 i u odnosu na dozu i u odnosu na vreme aplikacije.
Titel: |
The therapeutic effect of PAM-2 Cl on armin poisoned mice ; Terapijski učinak PAM-2-hlorida na miševima otrovanim arminom
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Autor/in / Beteiligte Person: | Binenfeld, Z. ; Vojvodić, V. ; Božić, V. |
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Zeitschrift: | Arhiv za higijenu rada i toksikologiju ; ISSN 0004-1254 (Print) ; ISSN 1848-6312 (Online) ; Volume 12 ; Issue 3-4, 1961 |
Veröffentlichung: | Institute for Medical Research and Occupational Health, 1961 |
Medientyp: | academicJournal |
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