Common variants at 19p13 are associated with susceptibility to ovarian cancer
In: 884 ; 880, 2010
Online
academicJournal
Zugriff:
Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world, accounting for 4% of the deaths from cancer in women1. We performed a three-phase genome-wide association study of EOC survival in 8,951 individuals with EOC (cases) with available survival time data and a parallel association analysis of EOC susceptibility. Two SNPs at 19p13.11, rs8170 and rs2363956, showed evidence of association with survival (overall P = 5 × 10−4 and P = 6 × 10−4, respectively), but they did not replicate in phase 3. However, the same two SNPs demonstrated genome-wide significance for risk of serous EOC (P = 3 × 10−9 and P = 4 × 10−11, respectively). Expression analysis of candidate genes at this locus in ovarian tumors supported a role for the BRCA1-interacting gene C19orf62, also known as MERIT40, which contains rs8170, in EOC development.
| Titel: |
Common variants at 19p13 are associated with susceptibility to ovarian cancer
|
|---|---|
| Autor/in / Beteiligte Person: | Bolton, KL ; Tyrer, J ; Song, H ; Ramus, SJ ; Notaridou, M ; Jones, C ; Sher, T ; Gentry-Maharaj, A ; Wozniak, E ; Tsai, Y-Y ; Weidhaas, J ; Paik, D ; Van den Berg, DJ ; Stram, DO ; Pearce, CL ; Wu, AH ; Brewster, W ; Anton-Culver, H ; Ziogas, A ; Narod, SA ; Levine, DA ; Kaye, SB ; Brown, R ; Paul, J ; Flanagan, J ; Sieh, W ; McGuire, V ; Whittemore, AS ; Campbell, I ; Gore, ME ; Lissowska, J ; Yang, HP ; Medrek, K ; Gronwald, J ; Lubinski, J ; Jakubowska, A ; Le, ND ; Cook, LS ; Kelemen, LE ; Brook-Wilson, A ; Massuger, LFAG ; Kiemeney, LA ; Aben, KKH ; Van Altena, AM ; Houlston, R ; Tomlinson, I ; Palmieri, RT ; Moorman, PG ; Schildkraut, J ; Iversen, ES ; Phelan, C ; Vierkant, RA ; Cunningham, JM ; Goode, EL ; Fridley, BL ; Kruger-Kjaer, S ; Blaeker, J ; Hogdall, E ; Hogdall, C ; Gross, J ; Karlan, BY ; Ness, RB ; Edwards, RP ; Odunsi, K ; Moyisch, KB ; Baker, JA ; Modugno, F ; Heikkinenen, T ; Butzow, R ; Nevanlinna, H ; Leminen, A ; Bogdanova, N ; Antonenkova, N ; Doerk, T ; Hillemanns, P ; Duerst, M ; Runnebaum, I ; Thompson, PJ ; Carney, ME ; Goodman, MT ; Lurie, G ; Wang-Gohrke, S ; Hein, R ; Chang-Claude, J ; Rossing, MA ; Cushing-Haugen, KL ; Doherty, J ; Chen, C ; Rafnar, T ; Besenbacher, S ; Sulem, P ; Stefansson, K ; Birrer, MJ ; Terry, KL ; Hernandez, D ; Cramer, DW ; Vergote, I ; Amant, F ; Lambrechts, D ; Despierre, E ; Fasching, PA ; Beckmann, MW ; Thiel, FC ; Ekici, AB ; Chen, X ; Johnatty, SE ; Webb, PM ; Beesley, J ; Chanock, S ; Garcia-Closas, M ; Sellers, T ; Easton, DF ; Berchuck, A ; Chenevix-Trench, G ; Pharoah, PDP ; Gayther, SA |
| Link: | |
| Zeitschrift: | 884 ; 880, 2010 |
| Veröffentlichung: | Nature Publishing Group, 2010 |
| Medientyp: | academicJournal |
| ISSN: | 1546-1718 (print) |
| DOI: | 10.1038/ng.666 |
| Schlagwort: |
|
| Sonstiges: |
|