The brain signature of paracetamol in healthy volunteers: a double-blind randomized trial
In: ISSN: 1177-8881 ; Drug Design, Development and Therapy ; https://hal.sorbonne-universite.fr/hal-01214449 ; Drug Design, 2015
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Zugriff:
International audience ; Background: Paracetamol’s (APAP) mechanism of action suggests the implication of supraspinal structures but no neuroimaging study has been performed in humans.Methods and results: This randomized, double-blind, crossover, placebo-controlled trial in 17 healthy volunteers (NCT01562704) aimed to evaluate how APAP modulates pain-evoked functional magnetic resonance imaging signals. We used behavioral measures and functional magnetic resonance imaging to investigate the response to experimental thermal stimuli with APAP or placebo administration. Region-of-interest analysis revealed that activity in response to noxious stimulation diminished with APAP compared to placebo in prefrontal cortices, insula, thalami, anterior cingulate cortex, and periaqueductal gray matter.Conclusion: These findings suggest an inhibitory effect of APAP on spinothalamic tracts leading to a decreased activation of higher structures, and a top-down influence on descending inhibition. Further binding and connectivity studies are needed to evaluate how APAP modulates pain, especially in the context of repeated administration to patients with pain.
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The brain signature of paracetamol in healthy volunteers: a double-blind randomized trial
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| Autor/in / Beteiligte Person: | Pickering, Gisèle ; Kastler, Adrian ; Macian, Nicolas ; Pereira, Bruno ; Valabregue, Romain ; Lehericy, Stéphane ; Boyer, Louis ; Dubray, Claude ; Jean, Betty ; Centre de Pharmacologie Clinique ; Laboratoire de Pharmacologie Médicale ; Université d'Auvergne - Clermont-Ferrand I (UdA) ; Service d’Imagerie Médicale et Radiologie Interventionnelle CHU Clermont-Ferrand ; CHU Gabriel Montpied Clermont-Ferrand ; CHU Clermont-Ferrand-CHU Clermont-Ferrand ; Centre d'Investigation Clinique CHU Clermont-Ferrand (CIC 1405) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Direction de la recherche clinique et de l’innovation CHU Clermont-Ferrand (DRCI) ; Délégation à la Recherche Clinique et à l'Innovation ; Clermont-Ferrand, CHU ; Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM) ; Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière AP-HP ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS) ; Image Science for Interventional Techniques (ISIT) ; Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université-Centre National de la Recherche Scientifique (CNRS) ; ANR-11-INBS-0006,FLI,France Life Imaging(2011) |
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| Zeitschrift: | ISSN: 1177-8881 ; Drug Design, Development and Therapy ; https://hal.sorbonne-universite.fr/hal-01214449 ; Drug Design, 2015 |
| Veröffentlichung: | HAL CCSD ; Dove Medical Press, 2015 |
| Medientyp: | academicJournal |
| DOI: | 10.2147/DDDT.S81004 |
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