Effects of clonixin on the electrical activity of cardiac pacemaker cells
In: General Pharmacology, 1992
academicJournal
Zugriff:
1. 1. The electrophysiological effects of clonixin, a non-steroidal analgesic, on cardiac pacemaker cells of spontaneously beating frog sinus venosus, were studied by intracellular recording of transmembrane potentials. 2. 2. Results show that clonixin (Clx) between 1 × 10-6 M and 3 × 10-4 M, decreases the OS, APA, Vmax and frequency of primary and subsidiary cells, however pacemaker cells differ in their sensitivity to Clx. 3. 3. At 2 × 10-6 M, Clx completely blocked the spontaneous beating of primary cells. It is necessary to increase the Clx concentration about two orders of magnitude in order to attain a similar degree of blockade of subsidiary cells. 4. 4. Previous or simultaneous superfusion with atropine does not modify Clx effects, thus a probable cholinergic mechanism of action for Clx is discarded. 5. 5. When Clx concentrations were lower than 5 × 10-4 M, their effects on both types of cells were partially reversed by a 100% increase of external calcium concentration. 6. 6. B
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Effects of clonixin on the electrical activity of cardiac pacemaker cells
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Autor/in / Beteiligte Person: | Morales ; Inostroza ; Salazar ; Paeile |
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Zeitschrift: | General Pharmacology, 1992 |
Veröffentlichung: | 1992 |
Medientyp: | academicJournal |
ISSN: | 0306-3623 (print) |
DOI: | 10.1016/0306-3623(92)90121-Y |
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