Helicobacter pylori cholesterol-α-glucosyltransferase manipulates cholesterol for bacterial adherence to gastric epithelial cells ...
Taylor & Francis, 2021
academicJournal
Zugriff:
Helicobacter pylori infection is associated with several gastrointestinal diseases, including gastritis, peptic ulcers, and gastric cancer. Infection of cells with H. pylori is dependent on lipid rafts, which are cholesterol-rich microdomains located in the cell membrane. H. pylori cholesterol-α-glucosyltransferase (CGT) catalyzes the conversion of membrane cholesterol to cholesteryl glucosides, which can be incorporated into the bacterial cell wall, facilitating evasion from immune defense and colonization in the host. However, the detailed mechanisms underlying this process remain to be explored. In this study, we discovered for the first time that H. pylori CGT could promote adherence to gastric epithelial cells in a cholesterol-dependent manner. Externalization of cell membrane phosphatidylserine (PS) is crucial for enhancement of binding of H. pylori to cells by CGT and for cytotoxin-associated gene A (CagA)-induced pathogenesis. Furthermore, exogenous cholesterol interferes with the actions of H. ...
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Helicobacter pylori cholesterol-α-glucosyltransferase manipulates cholesterol for bacterial adherence to gastric epithelial cells ...
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Autor/in / Beteiligte Person: | Hsu, Chung-Yao ; Yeh, Jia-Yin ; Chen, Chun-Ya ; Wu, Hui-Yu ; Chiang, Meng-Hsuan ; Wu, Chia-Lin ; Lin, Hwai-Jeng ; Chiu, Cheng-Hsun ; Lai, Chih-Ho |
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Veröffentlichung: | Taylor & Francis, 2021 |
Medientyp: | academicJournal |
DOI: | 10.6084/m9.figshare.16602476.v2 |
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