Classification of Non-Demented Patients Attending a Memory Clinic using the New Diagnostic Criteria for Alzheimer's Disease with Disease-Related Biomarkers.
In: Journal of Alzheimer's Disease, Vol. 43, no. 3, p. 835-847 (2015, 2015
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academicJournal
Zugriff:
Background: New diagnostic criteria for predemential Alzheimer's disease (AD) advocate the use of biomarkers. However, the benefit of using biomarkers has not been clearly demonstrated in clinical practice. Objective: To investigate whether a combination of biomarkers may be helpful in classifying a population of non-demented patients attending a Memory Clinic. Methods: Sixty non-demented patients were compared with 31 healthy elderly subjects. All subjects underwent a neuropsychological examination, brain 3T magnetic resonance imaging, and [F18]-fluorodeoxyglucose and [F18]-flutemetamol positron emission tomography. According to their performance on memory, language, executive, and visuo-spatial domains, the patients were classified as mild cognitive impairment (amnestic, non-amnestic, single, or multiple domain) or subjective cognitive impairment. Patients were then classified according to the National Institute on Aging-Alzheimer's Association (NIA-AA) criteria, using the normalized mean hippocampal volume (Freesurfer), [F18]-FDG PALZAD, and [F18]-flutemetamol standard uptake value ratio (SUVr) (cut-off at the 10th percentile of controls). The standard of truth was the clinical status at study entry (patient versus control). Results: The sensitivity/specificity of the clinical classification was 65/84%. The NIA-AA criteria were applicable in 85% of patients and 87% of controls. For biomarkers the best sensitivity (72%) at a fixed specificity of 84% was achieved by a combination of the three biomarkers. The clinical diagnosis was reconsidered in more than one third of the patients (42%) as a result of including the biomarker results. Conclusions: Application of the new NIA-AA AD diagnostic criteria based on biomarkers in an unselected sample of non-demented patients attending a Memory Clinic was useful in allowing for a better classification of the subjects.
Titel: |
Classification of Non-Demented Patients Attending a Memory Clinic using the New Diagnostic Criteria for Alzheimer's Disease with Disease-Related Biomarkers.
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Autor/in / Beteiligte Person: | Ivanoiu, Adrian ; Dricot, Laurence ; Gilis, Nathalie ; Grandin, Cécile ; Lhommel, Renaud ; Quenon, Lisa ; Hanseeuw, Bernard ; UCL - SSS/IONS/NEUR - Clinical Neuroscience ; UCL - (SLuc) Service de radiologie ; UCL - (SLuc) Service de neurologie ; UCL - (SLuc) Service de médecine nucléaire |
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Zeitschrift: | Journal of Alzheimer's Disease, Vol. 43, no. 3, p. 835-847 (2015, 2015 |
Veröffentlichung: | I O S Press, 2015 |
Medientyp: | academicJournal |
ISSN: | 1387-2877 (print) ; 1875-8908 (print) |
DOI: | 10.3233/JAD-140651 |
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