4-thioribose analogues of adenosine diphosphate ribose (ADPr) peptides
American Chemical Society, 2023
Online
academicJournal
Zugriff:
This is the final version. Available from the American Chemical Society via the DOI in this record. ; Data Availability Statement: The data underlying this study are available in the published article and its Supporting Information. ; Adenosine diphosphate (ADP) ribosylation is an important post-translational modification (PTM) that plays a role in a wide variety of cellular processes. To study the enzymes responsible for the establishment, recognition, and removal of this PTM, stable analogues are invaluable tools. We describe the design and synthesis of a 4-thioribosyl APRr peptide that has been assembled by solid phase synthesis. The key 4-thioribosyl serine building block was obtained in a stereoselective glycosylation reaction using an alkynylbenzoate 4-thioribosyl donor. ; Biotechnology and Biological Sciences Research Council ; Wellcome Trust ; Wellcome Trust ; Ovarian Cancer Research Alliance ; Netherlands Organization for Scientific Research (NWO)
Titel: |
4-thioribose analogues of adenosine diphosphate ribose (ADPr) peptides
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Autor/in / Beteiligte Person: | Madern, JM ; Voorneveld, J ; Rack, JGM ; Ahel, I ; van der Marel, GA ; Codée, JDC ; Filippov, DV |
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Veröffentlichung: | American Chemical Society, 2023 |
Medientyp: | academicJournal |
ISSN: | 1523-7060 (print) ; 1523-7052 (print) |
DOI: | 10.1021/acs.orglett.3c01554 |
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