Elucidation of GPR55-associated signaling behind THC and LPI reducing effects on Ki67-immunoreactive nuclei in patient-derived glioblastoma cells ...
Universitäts- und Landesbibliothek Sachsen-Anhalt, 2023
academicJournal
Zugriff:
GPR55 is involved in many physiological and pathological processes. In cancer, GPR55 has been described to show accelerating and decelerating effects in tumor progression resulting from distinct intracellular signaling pathways. GPR55 becomes activated by LPI and various plant-derived, endogenous, and synthetic cannabinoids. Cannabinoids such as THC exerted antitumor effects by inhibiting tumor cell proliferation or inducing apoptosis. Besides its effects through CB1 and CB2 receptors, THC modulates cellular responses among others via GPR55. Previously, we reported a reduction in Ki67-immunoreactive nuclei of human glioblastoma cells after GPR55 activation in general by THC and in particular by LPI. In the present study, we investigated intracellular mechanisms leading to an altered number of Ki67+ nuclei after stimulation of GPR55 by LPI and THC. Pharmacological analyses revealed a strongly involved PLC-IP3 signaling and cell-type-specific differences in Gα-, Gβγ-, RhoA-ROCK, and calcineurin signaling. ...
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Elucidation of GPR55-associated signaling behind THC and LPI reducing effects on Ki67-immunoreactive nuclei in patient-derived glioblastoma cells ...
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Autor/in / Beteiligte Person: | Kolbe, Marc Richard ; Hohmann, Tim ; Hohmann, Urszula ; Maronde, Erik ; Golbik, Ralph ; Prell, Julian ; Illert, Jörg ; Strauss, Christian ; Dehghani, Faramarz |
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Veröffentlichung: | Universitäts- und Landesbibliothek Sachsen-Anhalt, 2023 |
Medientyp: | academicJournal |
DOI: | 10.25673/113483 |
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