Effect of LDA, ASA or NSAIDs on miR-155 and miR-223 expression.
2021
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Zugriff:
(A) MiR-155 and (B) miR-223 expression levels in gastric antrum biopsies from healthy subjects of the LDA-study (n = 29) before and after 7 days of daily intake of LDA (100mg). (C) Expression of miR-155 in gastric antrum biopsies from patients with no ASA/NSAIDs (n = 113), with ASA (n = 25), NSAIDs (n = 34) or either of drugs (n = 70). (D) Expression of miR-155 in mucosa in patients with no PPI intake: no drugs (n = 65), ASA (n = 12), NSAIDs (n = 22) or ASA/NSAIDs (n = 36). (E) Expression of miR-223 in gastric antrum biopsies from patients with no ASA/NSAIDs (n = 57), with ASA (n = 13), NSAIDs (n = 17) or either of drugs (n = 36). (F) Expression of miR-223 in mucosa in patients with no PPI intake: no drugs (n = 34), ASA (n = 5), NSAIDs (n = 8) or ASA/NSAIDs (n = 17). MiRNA expression levels are shown as 2 ΔCT -values normalized to RNU6b and data are shown as box-plots where the horizontal line marks the median value.
Titel: |
Effect of LDA, ASA or NSAIDs on miR-155 and miR-223 expression.
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Autor/in / Beteiligte Person: | Riccardo Vasapolli (10654620) ; Marino Venerito (8207424) ; Wiebke Schirrmeister (10654623) ; Cosima Thon (10654626) ; Jochen Weigt (10654629) ; Thomas Wex (144817) ; Peter Malfertheiner (144819) ; Alexander Link (144815) |
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Veröffentlichung: | 2021 |
Medientyp: | Bild |
DOI: | 10.1371/journal.pone.0249282.g002 |
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