Repositioning TH cell polarization from single cytokines to complex help
In: ISSN: 1529-2908, 2021
academicJournal
Zugriff:
International audience ; When helper T (TH) cell polarization was initially described three decades ago, the TH cell universe grew dramatically. New subsets were described based on their expression of few specific cytokines. Beyond TH1 and TH2 cells, this led to the coining of various TH17 and regulatory (Treg) cell subsets as well as TH22, TH25, follicular helper (TFH), TH3, TH5 and TH9 cells. High-dimensional single-cell analysis revealed that a categorization of TH cells into a single-cytokine-based nomenclature fails to capture the complexity and diversity of TH cells. Similar to the simple nomenclature used to describe innate lymphoid cells (ILCs), we propose that TH cell polarization should be categorized in terms of the help they provide to phagocytes (type 1), to B cells, eosinophils and mast cells (type 2) and to non-immune tissue cells, including the stroma and epithelium (type 3). Studying TH cells based on their helper function and the cells they help, rather than phenotypic features such as individual analyzed cytokines or transcription factors, better captures TH cell plasticity and conversion as well as the breadth of immune responses in vivo.
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Repositioning TH cell polarization from single cytokines to complex help
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Autor/in / Beteiligte Person: | Tuzlak, Selma ; Dejean, Anne ; Iannacone, Matteo ; Quintana, Francisco ; Waisman, Ari ; Ginhoux, Florent ; Korn, Thomas ; Becher, Burkhard ; Universität Zürich Zürich = University of Zurich (UZH) ; Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity) ; Université Toulouse III - Paul Sabatier (UT3) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) ; IRCCS San Raffaele Scientific Institute Milan, Italie ; Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University Milan, Italie (UniSR) ; Brigham & Women’s Hospital Boston (BWH) ; Harvard Medical School Boston (HMS) ; University Medical Center of the Johannes Gutenberg-University Mainz ; Singapore Immunology Network (SIgN) ; Biomedical Sciences Institute (BMSI) ; Duke-NUS Medical School Singapore ; Shangaï Jiao Tong University Shangaï ; Technische Universität Munchen - Technical University Munich - Université Technique de Munich (TUM) ; Munich Cluster for systems neurology Munich (SyNergy) ; Technische Universität Munchen - Technical University Munich - Université Technique de Munich (TUM)-Ludwig Maximilian University Munich = Ludwig Maximilians Universität München (LMU) ; ARSEP foundation (ARSEP R19191BB ; (R20097BB), FRM ; Italian Ministry of Health grants RF-2018-12365801 and COVID-2020-12371617 ; Lombardy Foundation for Biomedical Research grant 2015-0010 ; ANR-16-CE15-0007,FOxOTiC,Rôle du facteur de transcription Foxo3 dans les lymphocytes T CD4(2016) ; European Project: 957502,ERC |
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Zeitschrift: | ISSN: 1529-2908, 2021 |
Veröffentlichung: | HAL CCSD ; Nature Publishing Group, 2021 |
Medientyp: | academicJournal |
DOI: | 10.1038/s41590-021-01009-w |
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