A 50-year record of quinolone and sulphonamide antimicrobial agents in Seine River sediments
In: ISSN: 1439-0108, 2011
academicJournal
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International audience ; Purpose: Even though sediments may represent a reservoir for antimicrobial agents, little is known about the persistence of these molecules over time or their accumulation. In this study, six antimicrobial agents, oxolinic acid, flumequine, nalidixic acid, norfloxacin, sulphamethoxazole and trimethoprim, were investigated in a sediment core from the Seine River. This work aimed to (1) measure antimicrobial agent contamination levels in the sediment and identify their origins, (2) obtain information on the persistence of these compounds in sediment over long periods (>4 years) and (3) show the existence of a historical record in sediment of river contamination by antimicrobial agents. Material and methods Sedimentary records were collected in a regularly flooded area at the side of the Seine River downstream of urban Paris. Dating was performed using environmental 137Cs and 210Pb radioisotopes. Antimicrobial agents were extracted and purified using Soxhlet extraction and solid phase extraction. Chromatographic separation of the compounds was achieved with Ultra Performance™ liquid chromatography tandem mass spectrometry. Results and discussion : Antimicrobial agent residues were detected in river sediment deposits to a depth exceeding 80 cm, corresponding to sediment deposits dating from the early 1960s. Five out of six antimicrobial agents were detected: norfloxacin, flumequine, oxolinic acid, nalidixic acid and sulphamethoxazole. Dating of the slices shows evidence of a correspondence between commercialisation of the compounds and their occurrence in the successive sediment deposits. In general, the results from previous studies justify the assumption of relative persistence of these compounds, although no experiments were conducted over periods as long as several decades. Conclusions : Our results show that antimicrobial agents can persist in sediment for up to 30 to 40 years, which raise concerns about the environmental effects of such long-term exposure on aquatic organisms.
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A 50-year record of quinolone and sulphonamide antimicrobial agents in Seine River sediments
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Autor/in / Beteiligte Person: | Tamtam, Fatima ; Le Bot, Barbara ; Dinh, Tuc ; Mompelat, Sophie ; Eurin, Joelle ; Chevreuil, Marc ; Bonte, Philippe ; Mouchel, Jean-Marie ; Ayrault, Sophie ; Laboratoire d'étude et de recherche en environnement et santé (LERES) ; École des Hautes Études en Santé Publique EHESP (EHESP) ; Institut de recherche en santé, environnement et travail (Irset) ; Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique EHESP (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) ; Structure et fonctionnement des systèmes hydriques continentaux (SISYPHE) ; Université Pierre et Marie Curie - Paris 6 (UPMC)-École Pratique des Hautes Études (EPHE) ; Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Mines Paris - PSL (École nationale supérieure des mines de Paris) ; Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS) ; Laboratoire des Sciences du Climat et de l'Environnement Gif-sur-Yvette (LSCE) ; Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)) ; Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA) ; Géochimie Des Impacts (GEDI) ; Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)) ; This research was financed by a doctoral grant from the Ile-de-France region. |
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Zeitschrift: | ISSN: 1439-0108, 2011 |
Veröffentlichung: | HAL CCSD ; Springer Verlag, 2011 |
Medientyp: | academicJournal |
DOI: | 10.1007/s11368-011-0364-1 |
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