The impact of micronized progesterone on breast cancer risk: a systematic review.
In: Stute, Petra; Wildt, L; Neulen, J (2018). The impact of micronized progesterone on breast cancer risk: a systematic review. Climacteric, 21(2), pp. 111-122. Informa Healthcare 10.1080/13697137.2017.1421925 <http://dx.doi.org/10.1080/13697137.2017.1421925>, 2018, S. 111-122
Online
academicJournal
Zugriff:
Postmenopausal women with an intact uterus using estrogen therapy should receive a progestogen for endometrial protection. The debate on bioidentical hormones including micronized progesterone has increased in recent years. Based on a systematic literature review on the impact of menopausal hormone therapy (MHT) containing micronized progesterone on the mammary gland, an international expert panel's recommendations are as follows: (1) estrogens combined with oral (approved) or vaginal (off-label use) micronized progesterone do not increase breast cancer risk for up to 5 years of treatment duration; (2) there is limited evidence that estrogens combined with oral micronized progesterone applied for more than 5 years are associated with an increased breast cancer risk; and (3) counseling on combined MHT should cover breast cancer risk - regardless of the progestogen chosen. Yet, women should also be counseled on other modifiable and non-modifiable breast cancer risk factors in order to balance the impact of combined MHT on the breast.
Titel: |
The impact of micronized progesterone on breast cancer risk: a systematic review.
|
---|---|
Autor/in / Beteiligte Person: | Stute, Petra ; Wildt, L ; Neulen, J |
Link: | |
Zeitschrift: | Stute, Petra; Wildt, L; Neulen, J (2018). The impact of micronized progesterone on breast cancer risk: a systematic review. Climacteric, 21(2), pp. 111-122. Informa Healthcare 10.1080/13697137.2017.1421925 <http://dx.doi.org/10.1080/13697137.2017.1421925>, 2018, S. 111-122 |
Veröffentlichung: | Informa Healthcare, 2018 |
Medientyp: | academicJournal |
DOI: | 10.1080/13697137.2017.1421925 |
Schlagwort: |
|
Sonstiges: |
|