Comparison of Extravascular volume by cardiac MR T1 mapping by conventional look locker versus modified look locker techniques to predict histologically measured fibrosis in valve disease
In: European Heart Journal Cardiovascular Imaging, Vol. 15, no.il2, p. i33 (2014, 2014
Online
Konferenz
Zugriff:
Background: Valvular heart disease is associated with left ventricular hypertrophy, remodeling and development of diffuse interstitial fibrosis. So far, histopathology remains the gold standard for evaluating diffuse myocardial fibrosis. Gadolinium enhanced Cardiac Magnetic Resonance (CMR) T1 mapping is new method which allows to quantify the myocardial extracellular volume (ECV). Look locker and modified look locker (MOLLI) are two techniques to assess ECV. Hence, it was suggested that the two techniques are equivalents. Therefore the aim of this study is to compare these two techniques against histological measurement. Methods and results: 18 patients (age=58±14 years, 72% men) with either severe aortic valve disease (stenosis or regurgitation) or severe mitral regurgitation, but without coronary artery disease preoperatively underwent ECV measurement by CMR two beat look locker and MOLLI 3-3-5 single breathhold T1 mapping. LV biopsies were performed at the time of surgery 24±38 days later and stained with Sirius red. The amount of fibrosis quantified by biopsy was 9.0±8.9% [2.1;39.2]. ECV by T1 mapping mesured by look locker normalized to heart rate of 60bpm was 38.7±13.9% [23.9;64.4] and by MOLLI was 28.7±4.8% [23.3;38.6] (values are presented as mean±SD [min;max]). The two T1 mapping values are significantly different (p=0,010). There was a good correlation between histologically measured fibrosis and T1 mapping ECV by MOLLI (r=0.72, p<0.001, cfr figure) but not by look locker (r=-0.16, p=0.52) mesurement. Conclusion: ECV determined by CMR T1 mapping mesured by MOLLI technique closely correlates with histologically determined diffuse interstitial fibrosis. By contrast the look locker method does not provide accurate mesurement of ECV, likely because the shot interval does not allow complete relaxation of T1.
Titel: |
Comparison of Extravascular volume by cardiac MR T1 mapping by conventional look locker versus modified look locker techniques to predict histologically measured fibrosis in valve disease
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Autor/in / Beteiligte Person: | de Meester de Ravenstein, Christophe ; Amzulescu, Mihaela Silvia ; Bouzin, Caroline ; Boileau, Laurianne ; Melchior, Julie ; Boulif, Jamila ; Lazam, Siham ; Pasquet, Agnes ; Vancraeynest, David ; Vanoverschelde, Jean-Louis ; Gerber, Bernhard ; EuroCMR ; UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire |
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Zeitschrift: | European Heart Journal Cardiovascular Imaging, Vol. 15, no.il2, p. i33 (2014, 2014 |
Veröffentlichung: | Oxford University Press, 2014 |
Medientyp: | Konferenz |
ISSN: | 2047-2404 (print) ; 2047-2412 (print) |
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